Model systems in stem cell biology

BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology
Jason Scott Robert

Abstract

Stem cell scientists and ethicists have focused intently on questions relevant to the developmental stage and developmental capacities of stem cells. Comparably less attention has been paid to an equally important set of questions about the nature of stem cells, their common characteristics, their non-negligible differences and their possible developmental species specificity. Answers to these questions are essential to the project of justly inferring anything about human stem cell biology from studies in non-human model systems--and so to the possibility of eventually developing human therapies based on stem cell biology. After introducing and discussing these questions, I conclude with a brief discussion of the creation of novel model systems in stem cell biology: human-to-animal embryonic chimeras. Such novel model systems may help to overcome obstacles to extrapolation, but they are also scientifically and ethically contentious.

References

Jan 1, 1991·Developmental Biology·J Maienschein
Feb 1, 1993·Trends in Neurosciences·N M Le Douarin
May 1, 1995·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·J A Bolker
Feb 26, 2000·Science·F M Watt, B L Hogan
Mar 10, 2000·Journal of Applied Physiology·R S Williams, P D Wagner
Dec 29, 2000·Transgenic Research·R M Petters, J R Sommer
Jan 3, 2001·JAMA : the Journal of the American Medical Association·E Juengst, M Fossel
Jul 6, 2001·Cell·H M BlauJ M Weimann
Sep 5, 2001·Nature Cell Biology·J G TomaF D Miller
Nov 1, 2001·Annual Review of Cell and Developmental Biology·I L WeissmanF Gage
May 8, 2002·The New England Journal of Medicine·Irving L Weissman
Jun 22, 2002·Nature·Yuehua JiangCatherine M Verfaillie
Jun 25, 2002·Journal of Molecular Biology·Donald M Bruce
Jul 5, 2002·Nature
Jul 13, 2002·The Journal of Pathology·Malcolm R AlisonNicholas A Wright
Jul 13, 2002·The Journal of Pathology·Anne E BishopJulia M Polak
Aug 31, 2002·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Ronald S GoldsteinNissim Benvenisty
Sep 13, 2002·Proceedings of the National Academy of Sciences of the United States of America·Jason A HackneyKateri A Moore
Sep 14, 2002·Science·Miguel Ramalho-SantosDouglas A Melton
Sep 14, 2002·Science·Natalia B IvanovaIhor R Lemischka
Dec 3, 2002·Nature Reviews. Genetics·Haifan Lin
Feb 11, 2003·Nature Biotechnology·Thomas P Zwaka, James A Thomson
Feb 20, 2003·Trends in Neurosciences·Raewyn M Seaberg, Derek van der Kooy
May 10, 2003·Science·Ali H BrivanlouJanet Rossant
Jul 10, 2003·Lancet Neurology·Anders BjörklundRoger Barker
Sep 12, 2003·Stem Cells·Maisam MitalipovaSteven Stice
Oct 18, 2003·Science·Gretchen Vogel
Nov 5, 2003·The American Journal of Bioethics : AJOB·Jason Scott Robert, Françoise Baylis
Nov 11, 2003·Fertility and Sterility·Liza DawsonRuth R Faden
Apr 2, 2004·Nature Medicine·Phillip KarpowiczDerek van der Kooy

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Citations

Jul 29, 2010·Journal of the History of Biology·Mary Evelyn Sunderland
Mar 17, 2007·The American Journal of Bioethics : AJOB·Rebecca A Martin, Jason Scott Robert
May 15, 2007·The American Journal of Bioethics : AJOB·Françoise Baylis, Jason Scott Robert
May 26, 2012·Bioinformatics·Yaki Setty
Jan 10, 2014·Theoretical Biology & Medical Modelling·Yaki Setty
Jun 26, 2007·Social Science & Medicine·Mita GiacominiJason Robert
Feb 16, 2006·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Stanley Shostak
Apr 17, 2016·Studies in History and Philosophy of Science·Melinda Bonnie Fagan
May 6, 2006·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jason Scott Robert
Apr 1, 2019·Advanced Biosystems·Alice C TaylorRichard B Jackman
May 16, 2018·Wiley Interdisciplinary Reviews. Developmental Biology·Jonathan M W Slack
Jul 16, 2005·Science·Mark GreeneRuth Faden

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