Modeled microgravity inhibits apoptosis in peripheral blood lymphocytes

In Vitro Cellular & Developmental Biology. Animal
D Risin, N R Pellis

Abstract

Microgravity interferes with numerous lymphocyte functions (expression of cell surface molecules, locomotion, polyclonal and antigen-specific activation, and the protein kinase C activity in signal transduction). The latter suggests that gravity may also affect programmed cell death (PCD) in lymphocyte populations. To test this hypothesis, we investigated spontaneous, activation- and radiation-induced PCD in peripheral blood mononuclear cells exposed to modeled microgravity (MMG) using a rotating cell culture system. The results showed significant inhibition of radiation- and activation-induced apoptosis in MMG and provide insights into the potential mechanisms of this phenomenon.

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Citations

Aug 3, 2004·Journal of Clinical Pharmacology·Annemarie GraebeHartmut Derendorf
Jun 24, 2006·Journal of Cellular Biochemistry·Nancy E WardDiana Risin
Jan 18, 2003·Journal of Cellular Biochemistry·C Ontiveros, Laura R McCabe
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Nov 25, 2018·International Journal of Molecular Sciences·Maria Moreno-VillanuevaHonglu Wu
Mar 2, 2019·In Vitro Cellular & Developmental Biology. Animal·Banglian DengJun Chen
Apr 28, 2020·BioMed Research International·Satoshi FurukawaAkihisa Takahashi
May 23, 2012·International Journal of Molecular Medicine·Michaël BeckSarah Baatout
Dec 16, 2020·International Journal of Molecular Sciences·Binod PrasadMarcus Krüger
Apr 15, 2021·Journal of Biological Engineering·Oscar Fabian Garcia-AponteBence Kozma
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Jul 6, 2021·Frontiers in Bioengineering and Biotechnology·Stefan RiwaldtDaniela Grimm

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Methods Mentioned

BETA
PMA
flow cytometry

Software Mentioned

Elite Immuno - 4
GraphPad Prism

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis