Modeling accumulations of particles in lung during chronic inhalation exposures that lead to impaired clearance.

Health Physics
R K WolffRoger O McClellan

Abstract

Chronic inhalation of insoluble particles of low toxicity that produce substantial lung burdens of particles, or inhalation of particles that are highly toxic to the lung, can impair clearance. This report describes model calculations of accumulations in lung of inhaled low-toxicity diesel exhaust soot and high-toxicity Ga2O3 particles. Lung burdens of diesel soot were measured periodically during a 24-mo exposure to inhaled diesel exhaust at soot concentrations of 0, 0.35, 3.5, and 7 mg m-3, 7 h d-1, 5 d wk-1. Lung burdens of Ga2O3 were measured for 1 y after a 4-wk exposure to 23 mg Ga2O3 m-3, 2 h d-1, 5 d wk-1. Lung burdens of Ga2O3 were measured for 1 y both studies using inhaled radiolabeled tracer particles. Simulation models fit the observed lung burdens of diesel soot in rats exposed to the 3.5- and 7-mg m-3 concentrations of soot only if it was assumed that clearance remained normal for several months, then virtually stopped. Impaired clearance from high-toxicity particles occurred early after accumulations of a low burden, but that from low-toxicity particles was evident only after months of exposure, when high burdens had accumulated in lung. The impairment in clearances of Ga2O3 particles and radiolabeled tracers wa...Continue Reading

Citations

Oct 29, 2015·Pharmaceutical Research·Winston OngHongming Chen
Feb 17, 1998·Risk Analysis : an Official Publication of the Society for Risk Analysis·L A Cox
May 9, 2012·Regulatory Toxicology and Pharmacology : RTP·Roger O McClellanJohn C Wall
Jan 1, 1991·Toxicologic Pathology·M A Dorato, R K Wolff

❮ Previous
Next ❯

Related Concepts

Related Feeds

Auditory Perception

Auditory perception is the ability to receive and interpret information attained by the ears. Here is the latest research on factors and underlying mechanisms that influence auditory perception.

Related Papers

Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology
R K WolffRoger O McClellan
Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology
K J NikulaJ L Mauderly
Annual Review of Pharmacology and Toxicology
Roger O McClellan
© 2022 Meta ULC. All rights reserved