Modeling and MANOVA studies on toxicity and endocrine potential of packaging materials exposed to different extraction schemes

Environmental Research
Natalia SzczepańskaJacek Namieśnik

Abstract

The stability of the linings of packaging that is in contact with the goods stored has been of major concern during decades of the development of packaging materials. In this work, an attempt was undertaken to assess the applicability of using two bioassays (Microtox® and XenoScreen YES/YAS) in estimating the stability of packaging (cans, caps, multilayer material) and the impact of their degradation on the toxicity of some simulated media. The assessment of the impact of packaging storage conditions (temperature, disinfection, preservation, extracting and washing solvents) was planned and performed with i) regression modeling of the experimental effects on the ecotoxicity readings, ii) ANOVA and MANOVA estimation of the experimental conditions as significant factors affecting the toxicity results and iii) FTIR analysis of the packages. It is shown that the effects of temperature and extraction solvents could be quantitatively assessed by the agreement between all methods applied. It can be stated that temperature and acidity as well as the alcohol content in the sensitive media have the greatest impact on the toxicity of the extract and thus on the stability of the internal lining and the extractability of xenobiotics.

Citations

Nov 23, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Błażej KudłakJacek Namieśnik
Dec 8, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Błażej KudłakStefan Tsakovski
Mar 18, 2021·Ecotoxicology·Ewa Liwarska-BizukojcKevin M Van Geem
Sep 8, 2021·Environmental Science & Technology·Lisa ZimmermannMartin Wagner

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