Modeling and Predicting Tumor Response in Radioligand Therapy

Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
Peter KlettingMatthias Eiber

Abstract

The aim of this work was to develop a theranostic method that allows prediction of prostate-specific membrane antigen (PSMA)-positive tumor volume after radioligand therapy (RLT) based on a pretherapeutic PET/CT measurement and physiologically based pharmacokinetic/pharmacodynamic (PBPK/PD) modeling at the example of RLT using 177Lu-labeled PSMA for imaging and therapy (PSMA I&T). Methods: A recently developed PBPK model for 177Lu-PSMA I&T RLT was extended to account for tumor (exponential) growth and reduction due to irradiation (linear quadratic model). Data from 13 patients with metastatic castration-resistant prostate cancer were retrospectively analyzed. Pharmacokinetic/pharmacodynamic parameters were simultaneously fitted in a Bayesian framework to PET/CT activity concentrations, planar scintigraphy data, and tumor volumes before and after (6 wk) therapy. The method was validated using the leave-one-out Jackknife method. The tumor volume after therapy was predicted on the basis of pretherapy PET/CT imaging and PBPK/PD modeling. Results: The relative deviation of the predicted and measured tumor volume for PSMA-positive tumor cells (6 wk after therapy) was 1% ± 40%, excluding 1 patient (prostate-specific antigen-negative) ...Continue Reading

References

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Dec 19, 2015·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Peter KlettingGerhard Glatting
Mar 18, 2016·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Clemens KratochwilUwe Haberkorn
Aug 11, 2016·European Journal of Nuclear Medicine and Molecular Imaging·Madhav Prasad YadavChandrasekhar Bal
Sep 24, 2016·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Shozo OkamotoMatthias Eiber
Oct 22, 2016·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Kambiz RahbarBernd Joachim Krause
Feb 9, 2018·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Nusrat J BegumPeter Kletting

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Citations

Jun 20, 2020·EJNMMI Physics·Andreas RinscheidGerhard Glatting
Oct 26, 2018·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Rudolf A Werner
Nov 28, 2019·Cancer Research·Alireza KarimianGeorge Sgouros
Jan 23, 2021·Cancer Biotherapy & Radiopharmaceuticals·Nouran R R ZaidGerhard Glatting
Nov 3, 2020·Nuklearmedizin. Nuclear Medicine·Nusrat Jihan BegumPeter Kletting
Nov 29, 2020·Seminars in Radiation Oncology·Stephen A Graves, Robert F Hobbs
Apr 30, 2021·European Journal of Nuclear Medicine and Molecular Imaging·An AertsMichael Lassmann
Jul 11, 2020·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Luis David Jiménez-FrancoPeter Kletting
Oct 11, 2020·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Tiffany G ChanBart Cornelissen
Oct 18, 2020·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Lachlan E McInnesPaul S Donnelly
Jun 30, 2021·Cancer Biotherapy & Radiopharmaceuticals·Nouran R R ZaidGerhard Glatting

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