Modeling and quantifying frequency-dependent fitness in microbial populations with cross-feeding interactions

Evolution; International Journal of Organic Evolution
Noah Ribeck, Richard E Lenski

Abstract

Coexistence of two or more populations by frequency-dependent selection is common in nature, and it often arises even in well-mixed experiments with microbes. If ecology is to be incorporated into models of population genetics, then it is important to represent accurately the functional form of frequency-dependent interactions. However, measuring this functional form is problematic for traditional fitness assays, which assume a constant fitness difference between competitors over the course of an assay. Here, we present a theoretical framework for measuring the functional form of frequency-dependent fitness by accounting for changes in abundance and relative fitness during a competition assay. Using two examples of ecological coexistence that arose in a long-term evolution experiment with Escherichia coli, we illustrate accurate quantification of the functional form of frequency-dependent relative fitness. Using a Monod-type model of growth dynamics, we show that two ecotypes in a typical cross-feeding interaction-such as when one bacterial population uses a byproduct generated by another-yields relative fitness that is linear with relative frequency.

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Citations

Mar 28, 2016·Trends in Genetics : TIG·Xuli ZhuRongling Wu
Jun 17, 2016·ELife·Mikhail Tikhonov
Jul 30, 2016·Artificial Life·Tim TaylorMichael Wiser
Dec 31, 2016·PLoS Computational Biology·Ivana GudeljFrank Rosenzweig
Mar 31, 2017·PLoS Computational Biology·Charles RocabertGuillaume Beslon
Apr 2, 2019·Artificial Life·Emily L DolsonCharles Ofria
Jul 6, 2019·Evolution; International Journal of Organic Evolution·Yeongseon Park, Yuseob Kim
May 6, 2019·Nature Communications·Lori NiehausBabak Momeni
May 27, 2020·Journal of the Royal Society, Interface·Olga A NevIvana Gudelj
May 26, 2018·Natural Product Reports·Glen D'SouzaChristian Kost
Sep 26, 2020·Frontiers in Bioengineering and Biotechnology·Eva Balsa-CantoAmparo Querol
Jul 27, 2018·Microbiology and Molecular Biology Reviews : MMBR·Bram Van den BerghJan Michiels
Jun 30, 2019·Proceedings of the National Academy of Sciences of the United States of America·Yoav RamLilach Hadany
Oct 14, 2020·Environmental Microbiology·Margaret A Knight, J Jeffrey Morris
Jul 1, 2021·Microbiology Spectrum·Marcelo Malisano Barreto FilhoJ Jeffrey Morris

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