PMID: 8876249Oct 15, 1996

Modeling back propagating action potential in weakly excitable dendrites of neocortical pyramidal cells

Proceedings of the National Academy of Sciences of the United States of America
M RappIdan Segev

Abstract

Simultaneous recordings from the soma and apical dendrite of layer V neocortical pyramidal cells of young rats show that, for any location of current input, an evoked action potential (AP) always starts at the axon and then propagates actively, but decrementally, backward into the dendrites. This back-propagating AP is supported by a low density (-gNa = approximately 4 mS/cm2) of rapidly inactivating voltage-dependent Na+ channels in the soma and the apical dendrite. Investigation of detailed, biophysically constrained, models of reconstructed pyramidal cells shows the following. (i) The initiation of the AP first in the axon cannot be explained solely by morphological considerations; the axon must be more excitable than the soma and dendrites. (ii) The minimal Na+ channel density in the axon that fully accounts for the experimental results is about 20-times that of the soma. If -gNa in the axon hillock and initial segment is the same as in the soma [as recently suggested by Colbert and Johnston [Colbert, C. M. & Johnston, D. (1995) Soc. Neurosci. Abstr. 21, 684.2]], then -gNa in the more distal axonal regions is required to be about 40-times that of the soma. (iii) A backward propagating AP in weakly excitable dendrites can be...Continue Reading

References

Apr 29, 2006·The Journal of Membrane Biology·B A MilojkovicS D Antic
Jul 27, 2012·Neuroscience Bulletin·Wenqin Hu, Yousheng Shu
Nov 1, 1992·Trends in Neurosciences·J M Bower, C Koch
Jun 27, 2002·Journal of Neuroscience Methods·Enric Claverol-Tinture, Jerome Pine
Oct 24, 2002·Trends in Neurosciences·Claude Meunier, Idan Segev
Mar 1, 1997·Trends in Neurosciences·G J StuartM Häusser
Aug 18, 2000·Neural Networks : the Official Journal of the International Neural Network Society·T Kitajima, K Hara
Aug 28, 2004·Nature Neuroscience·Michael London, Idan Segev
Jun 20, 1998·Proceedings. Biological Sciences·G T Kenyon, D W Marshak
Mar 11, 2004·Journal of Integrative Neuroscience·Roman R Poznanski
Jul 12, 2013·Annual Review of Neuroscience·Guy MajorJ Schiller
Mar 29, 2008·PLoS Computational Biology·Isaac ShemerSten Grillner
Dec 21, 2013·Proceedings of the National Academy of Sciences of the United States of America·Bardia F Behabadi, Bartlett W Mel
Oct 24, 2012·The Journal of Physiology·Wenzhi SunWayne N Frankel
Jul 11, 2012·Computational and Mathematical Methods in Medicine·Eduard KuriscakZdenek Wünsch
Feb 19, 2008·The European Journal of Neuroscience·Wen-Liang ZhouS D Antic
May 23, 2015·Frontiers in Computational Neuroscience·Alessandra PaffiMicaela Liberti
Oct 9, 2004·Progress in Biophysics and Molecular Biology·Jack WatersB Sakmann
Oct 9, 2014·Frontiers in Cellular Neuroscience·Cuiping TianYousheng Shu
Aug 19, 2016·Journal of Neurophysiology·Mara Almog, Alon Korngreen
May 11, 2005·Journal of Neurobiology·Allan T GulledgeG J Stuart
Nov 9, 2002·Journal of Neurophysiology·Wei R ChenJens Midtgaard
Nov 9, 2002·Journal of Neurophysiology·David Tsay, R Yuste
Feb 23, 2007·Journal of Neurophysiology·Julian P Meeks, Steven Mennerick
Apr 30, 2011·Physiological Reviews·Dominique DebanneGisèle Alcaraz

Citations

Dec 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·O BernanderC Koch
Nov 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·D A Wollner, W A Catterall
Mar 1, 1989·International Journal of Bio-medical Computing·M Hines
May 24, 1994·Proceedings of the National Academy of Sciences of the United States of America·H Markram, B Sakmann
Jun 1, 1993·Pflügers Archiv : European journal of physiology·G J StuartB Sakmann
Dec 1, 1995·Neuron·Z F MainenT J Sejnowski

Related Concepts

Initial Segment of Axon
AMPA, (S)-Isomer, Monohydrobromide
Action Potentials
Internal Pyramidal Layer of Cerebral Cortex
Transcription Initiation
Cell Communication
Axon
Synapses
GABA-A Receptor gamma Subunit
Potentials, Event-Related

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