Modeling blood-brain barrier pathology in cerebrovascular disease in vitro: current and future paradigms.

Fluids and Barriers of the CNS
Anuska V AndjelkovicRichard F Keep

Abstract

The complexity of the blood-brain barrier (BBB) and neurovascular unit (NVU) was and still is a challenge to bridge. A highly selective, restrictive and dynamic barrier, formed at the interface of blood and brain, the BBB is a "gatekeeper" and guardian of brain homeostasis and it also acts as a "sensor" of pathological events in blood and brain. The majority of brain and cerebrovascular pathologies are associated with BBB dysfunction, where changes at the BBB can lead to or support disease development. Thus, an ultimate goal of BBB research is to develop competent and highly translational models to understand mechanisms of BBB/NVU pathology and enable discovery and development of therapeutic strategies to improve vascular health and for the efficient delivery of drugs. This review article focuses on the progress being made to model BBB injury in cerebrovascular diseases in vitro.

References

Dec 1, 1992·The Journal of Investigative Dermatology·E W AdesT J Lawley
May 1, 1990·Journal of Neurochemistry·M P DehouckR Cecchelli
Apr 11, 1980·Science·K K ParkerA Vernadakis
Nov 1, 1981·Brain Research Bulletin·H M DuvernoyJ L Vannson
Sep 1, 1993·The American Journal of Physiology·D JanigroH R Winn
Jan 1, 1993·Advances in Experimental Medicine and Biology·R F KeepA L Betz
May 1, 1993·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·L WeiJ Fenstermacher
Oct 1, 1996·Current Opinion in Neurobiology·J M Staddon, L L Rubin
Apr 29, 1998·Annual Review of Physiology·L L Mitic, J M Anderson
Aug 11, 1999·Trends in Neurosciences·U DirnaglM A Moskowitz
Sep 4, 1999·In Vitro Cellular & Developmental Biology. Animal·T N PriceL V Mayne
Sep 18, 1999·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·B GaoP J Meier
May 4, 2000·Journal of Neurosurgery·R B WillemseJ G Wolbers
Jul 14, 2000·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·W ZhangD Stanimirovic
Sep 1, 2000·Seminars in Cell & Developmental Biology·L González-MariscalA Avila-Flores
May 8, 2001·Cells, Tissues, Organs·G Allt, J G Lawrenson
May 22, 2001·Journal of Neurochemistry·T MeguroJ H Zhang
Jul 10, 2001·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·C Loeb
Jul 18, 2001·Brain Research. Molecular Brain Research·O BraissantC Bachmann
Oct 13, 2001·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·H TakanagaT Terasaki
Oct 2, 2002·Neuroscience Research·Kentaro WakayamaTetsuya Terasaki
Oct 17, 2002·Emergency Medicine Clinics of North America·Peter D PanagosJoseph P Broderick
Oct 22, 2002·American Journal of Physiology. Cell Physiology·Momoh A Yakubu, Charles W Leffler
Dec 12, 2002·Progress in Biophysics and Molecular Biology·L González-MariscalB E Jaramillo
May 14, 2003·The Journal of Cell Biology·Takehiro NittaShoichiro Tsukita
Sep 5, 2003·International Journal of Pharmaceutics·Fried FaassenHerman Vromans
Nov 6, 2003·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Anuska V AndjelkovicRichard F Keep
Nov 19, 2003·Journal of Neurochemistry·Kazuhiro TetsukaTetsuya Terasaki
Nov 3, 2004·Regulatory Peptides·Kentaro HayashiMasami Niwa
Jan 11, 2005·The Journal of Pharmacy and Pharmacology·T TaogoshiM Takano
Jun 21, 2005·Cellular and Molecular Neurobiology·Máiria A DeliMasami Niwa
Sep 6, 2005·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·B B WekslerP O Couraud
Sep 30, 2005·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Oliver B DimitrijevicAnuska V Andjelkovic
Nov 18, 2005·Brain Research. Brain Research Reviews·Char-Huei LaiJoyce M Leo
Jun 14, 2006·Brain Research Reviews·Mehmet Cansev
Sep 26, 2006·Journal of Cellular Physiology·Sumio OhtsukiTetsuya Terasaki
Jul 5, 2007·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Luca CuculloDamir Janigro

❮ Previous
Next ❯

Citations

Dec 3, 2020·International Journal of Molecular Sciences·Ji Hae SeoKen Arai
Dec 16, 2020·Neural Regeneration Research·Martin A SchickWinfried Neuhaus
May 11, 2021·Frontiers in Cell and Developmental Biology·Xiangfu MengDonghui Zhang
Jun 5, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Honglin XiangLing Zhang
Aug 7, 2021·Therapeutic Delivery·Giovanni TosiBarbara Ruozi

❮ Previous
Next ❯

Methods Mentioned

BETA
chip
transfection

Software Mentioned

TEER
μBBB
BBB
SyM
DIV

Related Concepts

Related Feeds

Blood Brain Barrier Chips

The blood brain barrier (BBB) is comprised of endothelial cells that regulate the influx and outflux of plasma concentrations. Lab-on-a-chip devices allow scientists to model diseases and mechanisms such as the passage of therapeutic antibodies across the BBB. Discover the latest research on BBB chips here.

Blood Brain Barrier Regulation in Health & Disease

The blood brain barrier is essential in regulating the movement of molecules and substances in and out of the brain. Disruption to the blood brain barrier and changes in permeability allow pathogens and inflammatory molecules to cross the barrier and may play a part in the pathogenesis of neurodegenerative disorders. Here is the latest research in this field.

Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.

Blood Brain Barrier

The blood brain barrier is a border that separates blood from cerebrospinal fluid. Discover the latest search on this highly selective semipermeable membrane here.

Related Papers

Brain and nerve = Shinkei kenkyū no shinpo
Yukio Takeshita, Takashi Kanda
Nihon yakurigaku zasshi. Folia pharmacologica Japonica
Shinsuke Nakagawa, Masami Niwa
Current Opinion in Biomedical Engineering
Benjamin D GastfriendEric V Shusta
© 2021 Meta ULC. All rights reserved