The degree to which chronic glycemic exposure (CGE) (fasting plasma glucose [FPG], HbA1c [A1C], duration of diabetes, age at onset of diabetes, or combinations of these) is associated with or predicts the severity of microvessel complications is unsettled. Specifically, we test whether combinations of components correlate and predict complications better than individual components. Correlations and predictions of CGE and complications were assessed in the Rochester Diabetic Neuropathy Study, a population-based, cross-sectional, and longitudinal epidemiologic survey of 504 patients with diabetes followed for up to 20 years. In multivariate analysis, A1C and duration of diabetes (and to a lesser degree age at onset of diabetes but not FPG) were the main significant CGE risk covariates for complications. A derived glycemic exposure index (GE(i)) correlated with and predicted complications better than did individual components. Composite or staged measures of polyneuropathy provided higher correlations and better predictions than did dichotomous measures of whether polyneuropathy was present or not. Generally, the mean GE(i) was significantly higher with increasing stages of severity of complications. A combination of A1C, duration...Continue Reading
The Rochester Diabetic Neuropathy Study: design, criteria for types of neuropathy, selection bias, and reproducibility of neuropathic tests
Epidemiological correlates of diabetic neuropathy. Report from Pittsburgh Epidemiology of Diabetes Complications Study
Variables influencing neuropathic endpoints: the Rochester Diabetic Neuropathy Study of Healthy Subjects
The effect of 8 years of strict glycaemic control on peripheral nerve function in IDDM patients: the Oslo Study
The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus
Diabetic peripheral neuropathy: a clinicopathologic and immunohistochemical analysis of sural nerve biopsies
Risk factors for severity of diabetic polyneuropathy: intensive longitudinal assessment of the Rochester Diabetic Neuropathy Study cohort
Are predictors of coronary heart disease and lower-extremity arterial disease in type 1 diabetes the same? A prospective study
The relation of glycaemia to the risk of development and progression of retinopathy in the Diabetic Control and Complications Trial
Individual attributes versus composite scores of nerve conduction abnormality: sensitivity, reproducibility, and concordance with impairment
Retinal vascular abnormalities in persons with type 1 diabetes: the Wisconsin Epidemiologic Study of Diabetic Retinopathy: XVIII
History of standard scoring, notation, and summation of neuromuscular signs. A current survey and recommendation
Monotonicity of nerve tests in diabetes: subclinical nerve dysfunction precedes diagnosis of polyneuropathy
A controlled study of medial arterial calcification of legs: implications for diabetic polyneuropathy.
DCCT and EDIC studies in type 1 diabetes: lessons for diabetic neuropathy regarding metabolic memory and natural history.
Functional relevance of genetic variations of endothelial nitric oxide synthase and vascular endothelial growth factor in diabetic coronary microvessel dysfunction
Serum levels of TNF-α in peripheral neuropathy patients and its correlation with nerve conduction velocity in type 2 diabetes mellitus
Insulin resistance is independently associated with peripheral and autonomic neuropathy in Korean type 2 diabetic patients
Can glycaemic variability, as calculated from blood glucose self-monitoring, predict the development of complications in type 1 diabetes over a decade?
Does impaired glucose metabolism cause polyneuropathy? Review of previous studies and design of a prospective controlled population-based study
Effects of prior hypoglycemia and hyperglycemia on cognition in children with type 1 diabetes mellitus
Diabetic polyneuropathies: update on research definition, diagnostic criteria and estimation of severity
Polyneuropathy in type 1 and type 2 diabetes: comparison of nerve conduction studies, thermal perception thresholds and intraepidermal nerve fibre densities
Delayed Gastric Emptying Is Associated With Early and Long-term Hyperglycemia in Type 1 Diabetes Mellitus
Near-normoglycaemia and development of neuropathy: a 24-year prospective study from diagnosis of type 1 diabetes
American Association of Clinical Endocrinologists Medical Guidelines for Clinical Practice for developing a diabetes mellitus comprehensive care plan
American association of clinical endocrinologists and american college of endocrinology - clinical practice guidelines for developing a diabetes mellitus comprehensive care plan - 2015.
Role of ATP-sensitive K+ channels in the antinociception induced by non-steroidal anti-inflammatory drugs in streptozotocin-diabetic and non-diabetic rats
The role of insulin resistance in diabetic neuropathy in Koreans with type 2 diabetes mellitus: a 6-year follow-up study
Prevalence of polyneuropathy in pre-diabetes and diabetes is associated with abdominal obesity and macroangiopathy: the MONICA/KORA Augsburg Surveys S2 and S3
Large-fiber dysfunction in diabetic peripheral neuropathy is predicted by cardiovascular risk factors.
Diabetic neuropathies: update on definitions, diagnostic criteria, estimation of severity, and treatments
Metanx alleviates multiple manifestations of peripheral neuropathy and increases intraepidermal nerve fiber density in Zucker diabetic fatty rats.
Low peripheral nerve conduction velocities and amplitudes are strongly related to diabetic microvascular complications in type 1 diabetes: the EURODIAB Prospective Complications Study.
Small- and large-fiber neuropathy after 40 years of type 1 diabetes: associations with glycemic control and advanced protein glycation: the Oslo Study
Serum levels of TGF-β1 in patients of diabetic peripheral neuropathy and its correlation with nerve conduction velocity in type 2 diabetes mellitus
Prevention of cardiovascular disease through reduction of glycaemic exposure in type 2 diabetes: A perspective on glucose-lowering interventions
Association Between Diabetic Microangiopathies and Glycemic Variability Assessed by Continuous Glucose Monitoring
Prevalence and correlates of diabetic peripheral neuropathy in a Saudi Arabic population: a cross-sectional study
Inter-practitioner comparisons of nerve conduction studies with standardized techniques in normal subjects: Reap as you sow
Diagnostic performance of two-dimensional shear wave elastography for evaluating tibial nerve stiffness in patients with diabetic peripheral neuropathy
A formula based on autonomic test using EZSCAN and anthropometric data for diagnosis of DM in China.
Correlations Between Glycemic Parameters Obtained from Continuous Glucose Monitoring and Hemoglobin A1c and Glycoalbumin Levels in Type 2 Diabetes Mellitus.
Electrodiagnostic assessment of the autonomic nervous system: A consensus statement endorsed by the American Autonomic Society, American Academy of Neurology, and the International Federation of Clinical Neurophysiology.
Mean and visit-to-visit variability of glycemia and left ventricular diastolic dysfunction: A longitudinal analysis of 3025 adults with serial echocardiography.
American Diabetes Association Journals
Discover the latest diabetes research published by the journals from the American Diabetes Association.