Modeling chronic glycemic exposure variables as correlates and predictors of microvascular complications of diabetes

Diabetes Care
P J DyckPeter C O'Brien


The degree to which chronic glycemic exposure (CGE) (fasting plasma glucose [FPG], HbA1c [A1C], duration of diabetes, age at onset of diabetes, or combinations of these) is associated with or predicts the severity of microvessel complications is unsettled. Specifically, we test whether combinations of components correlate and predict complications better than individual components. Correlations and predictions of CGE and complications were assessed in the Rochester Diabetic Neuropathy Study, a population-based, cross-sectional, and longitudinal epidemiologic survey of 504 patients with diabetes followed for up to 20 years. In multivariate analysis, A1C and duration of diabetes (and to a lesser degree age at onset of diabetes but not FPG) were the main significant CGE risk covariates for complications. A derived glycemic exposure index (GE(i)) correlated with and predicted complications better than did individual components. Composite or staged measures of polyneuropathy provided higher correlations and better predictions than did dichotomous measures of whether polyneuropathy was present or not. Generally, the mean GE(i) was significantly higher with increasing stages of severity of complications. A combination of A1C, duration...Continue Reading


Dec 1, 1985·Brain : a Journal of Neurology·P J DyckF J Service
Jan 1, 1981·The American Journal of Medicine·D PorteE Halar
Jan 1, 1995·Neurology·P C O'Brien, P J Dyck
Sep 30, 1993·The New England Journal of Medicine·UNKNOWN Diabetes Control and Complications Trial Research GroupC Siebert
Aug 28, 2002·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Peter J DyckUNKNOWN rhNGF group
Oct 28, 2003·Diabetes Care·Saul GenuthUNKNOWN Expert Committee on the Diagnosis and Classification of Diabetes Mellitus
Jun 17, 2005·Journal of the Peripheral Nervous System : JPNS·Peter J DyckRaul Espinosa
Dec 22, 2005·Nature Genetics·Helge RaederPål Rasmus Njølstad
Jan 18, 2006·Nature Genetics·Struan F A GrantKari Stefansson

❮ Previous
Next ❯


May 14, 2010·Current Diabetes Reports·Rodica Pop-BusuiUNKNOWN DCCT/EDIC Research Group
Apr 29, 2010·Current Neurology and Neuroscience Reports·Ali A Habib, Thomas H Brannagan
Jul 5, 2008·Journal of Medicinal Food·Rebecca P DearloveJames L Hargrove
Aug 24, 2012·Postgraduate Medicine·Sarkis Morales-VidalAlejandro Hornik
Jan 26, 2016·Biochimica Et Biophysica Acta·Andrea CaporaliCostanza Emanueli
Dec 15, 2015·Journal of the Peripheral Nervous System : JPNS·Sissel LøsethSvein I Mellgren
Jun 23, 2011·Diabetes/metabolism Research and Reviews·Peter J DyckUNKNOWN Toronto Expert Panel on Diabetic Neuropathy
Jul 19, 2013·Muscle & Nerve·Peter J DyckUNKNOWN Clinical vs. Neurophysiology Trial 3 Investigators
Mar 12, 2010·Journal of Clinical Pharmacology·Petra M JauslinMats O Karlsson
May 20, 2015·Gastroenterology·Adil E BharuchaUNKNOWN Diabetes Control and Complications Trial–Epidemiology of Diabetes Interventions and Complications Research Group
Jun 8, 2015·Journal of the Neurological Sciences·C D KassardjianP J Dyck
Apr 16, 2011·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Yehuda HandelsmanUNKNOWN AACE Task Force for Developing Diabetes Comprehensive Care Plan
Nov 1, 2008·The Journal of the American Dental Association·Srividya Kidambi, Shailendra B Patel
Apr 15, 2015·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Yehuda HandelsmanFarhad Zangeneh
Jul 10, 2009·Diabetes Care·Jackie ElliottUNKNOWN EURODIAB Prospective Complications Study Group
Feb 23, 2012·Diabetes Care·Peter J DyckWilliam J Litchy
Sep 30, 2010·Diabetes Care·Solomon TesfayeUNKNOWN Toronto Diabetic Neuropathy Expert Group
May 28, 2016·Circulation Research·Joshua A Beckman, Mark A Creager
Sep 25, 2018·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Liborio RampelloAntonio Arcidiacono
Oct 15, 2011·Muscle & Nerve·Peter J DyckWilliam J Litchy
Mar 25, 2020·Diabetology International·Hideyuki SasakiPhillip A Low
Jan 10, 2021·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·William P CheshireWolfgang Singer
Feb 24, 2021·Diabetes, Obesity & Metabolism·Fu-Rong LiXian-Bo Wu
Oct 18, 2007·Current Opinion in Endocrinology, Diabetes, and Obesity

❮ Previous
Next ❯

Related Concepts

Related Feeds

American Diabetes Association Journals

Discover the latest diabetes research published by the journals from the American Diabetes Association.