Feb 24, 2017

Modeling Continuous Admixture Using Admixture-Induced Linkage Disequilibrium

Scientific Reports
Y ZhouShuhua Xu

Abstract

Recent migrations and inter-ethnic mating of long isolated populations have resulted in genetically admixed populations. To understand the complex population admixture process, which is critical to both evolutionary and medical studies, here we used admixture induced linkage disequilibrium (LD) to infer continuous admixture events, which is common for most existing admixed populations. Unlike previous studies, we expanded the typical continuous admixture model to a more general scenario with isolation after a certain duration of continuous gene flow. Based on the new models, we developed a method, CAMer, to infer the admixture history considering continuous and complex demographic process of gene flow between populations. We evaluated the performance of CAMer by computer simulation and further applied our method to real data analysis of a few well-known admixed populations.

  • References16
  • Citations1

Mentioned in this Paper

In Silico
Study
Isolation Aspects
Dysequilibrium Syndrome
Genetics, Population
Ethnic Group
Linkage Disequilibrium
Simulation
Analysis
Genetic Linkage

Related Feeds

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.