Sep 8, 2015

Modeling Continuous Admixture

BioRxiv : the Preprint Server for Biology
Ying ZhouShuhua Xu

Abstract

Human migration and human isolation serve as the driving forces of modern human civilization. Recent migrations of long isolated populations has resulted in genetically admixed populations. The history of population admixture is generally complex; however, understanding the admixture process is critical to both evolutionary and medical studies. Here, we utilized admixture induced linkage disequilibrium (LD) to infer occurrence of continuous admixture events, which is common for most existing admixed populations. Unlike previous studies, we expanded the typical continuous admixture model to a more general admixture scenario with isolation after a certain duration of continuous gene flow, and we demonstrated that such treatment significantly improved the accuracy of inference under complex admixture scenarios. Based on the extended models, we developed a method based on weighted LD to infer the admixture history considering continuous and complex demographic process of gene flow between populations. We evaluated the performance of the method by computer simulation and applied our method to real data analysis of a few well-known admixed populations.

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Mentioned in this Paper

Study
Isolation Aspects
Dysequilibrium Syndrome
Simulation
Analysis
Genetic Linkage
Migration, Cell
Population Group
Gene Flow

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