Modeling determinants of medication attitudes and poor adherence in early nonaffective psychosis: implications for intervention

Schizophrenia Bulletin
Richard James DrakeShôn Lewis

Abstract

We aimed to design a multimodal intervention to improve adherence following first episode psychosis, consistent with current evidence. Existing literature identified medication attitudes, insight, and characteristics of support as important determinants of adherence to medication: we examined medication attitudes, self-esteem, and insight in an early psychosis cohort better to understand their relationships. Existing longitudinal data from 309 patients with early Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, nonaffective psychosis (83% first episode) were analyzed to test the hypothesis that medication attitudes, while meaningfully different from "insight," correlated with insight and self-esteem, and change in each influenced the others. Rosenberg Self-Esteem Scale, Birchwood Insight Scale, and Positive and Negative Syndrome Scale insight were assessed at presentation, after 6 weeks and 3 and 18 months. Drug Attitudes Inventory (DAI) and treatment satisfaction were rated from 6 weeks onward. Structural equation models of their relationships were compared. Insight measures' and DAI's predictive validity were compared against relapse, readmission, and remission. Analysis found five latent constructs best...Continue Reading

References

Mar 1, 1985·The Journal of Nervous and Mental Disease·D W HeinrichsW T Carpenter
Jan 1, 1987·Schizophrenia Bulletin·S R KayL A Opler
Jul 1, 1987·The British Journal of Psychiatry : the Journal of Mental Science·C BarrowcloughH L Freeman
Jun 1, 1981·The American Journal of Psychiatry·T H McGlashan, W T Carpenter
Jan 1, 1994·Acta Psychiatrica Scandinavica·M BirchwoodM Slade
Jan 1, 1994·Schizophrenia Bulletin·P WeidenA Frances
Apr 16, 1998·The British Journal of Psychiatry : the Journal of Mental Science·V PatelA Mann
Sep 25, 1998·The British Journal of Psychiatry : the Journal of Mental Science·R KempA David
Oct 18, 2000·The British Journal of Clinical Psychology·A MooreJ Stirling
Jun 5, 2001·The British Journal of Psychiatry : the Journal of Mental Science·G HarrisonD Wiersma
Oct 19, 2001·Social Psychiatry and Psychiatric Epidemiology·B SvedbergJ Cullberg
Mar 5, 2002·Psychiatric Services : a Journal of the American Psychiatric Association·Ramin MojtabaiEvelyn J Bromet
Sep 13, 2002·Acta Psychiatrica Scandinavica·E L ColdhamD Addington
Sep 26, 2002·The British Journal of Psychiatry. Supplement·S LewisG Dunn
Oct 3, 2002·The American Journal of Psychiatry·Annette ZygmuntDavid Mechanic
Feb 4, 2003·The British Journal of Psychiatry : the Journal of Mental Science·Lynda TaitPeter Trower
May 27, 2003·Schizophrenia Research·Katherine N ThompsonSusan M Harrigan
Oct 1, 2003·Journal of Consulting and Clinical Psychology·Golan Shahar, Larry Davidson
Dec 25, 2003·Schizophrenia Research·Peter J WeidenDiana D McDonnell
Feb 6, 2004·Psychiatric Services : a Journal of the American Psychiatric Association·Hans RittmannsbergerJohannes Wancata
Feb 26, 2004·Psychological Medicine·R J DrakeS W Lewis
Mar 3, 2004·The British Journal of Psychiatry : the Journal of Mental Science·Nicholas TarrierGraham Dunn
Nov 2, 2004·The British Journal of Psychiatry : the Journal of Mental Science·Lynda TaitPeter Trower
Mar 3, 2005·The American Journal of Psychiatry·Nancy C AndreasenDaniel R Weinberger
Mar 16, 2005·The Journal of Clinical Psychiatry·Mark OlfsonEskinder Tafesse
Feb 16, 2006·The Journal of Nervous and Mental Disease·Nai-Ying KoCheng-Fang Yen
Mar 15, 2006·Schizophrenia Research·Diana O PerkinsUNKNOWN HGDH Research Group
May 3, 2006·The Journal of Clinical Psychiatry·Gabriele Pitschel-WalzWerner Kissling
May 19, 2006·Schizophrenia Bulletin·Dawn I VelliganAlexander L Miller
Jun 3, 2006·Psychological Medicine·Joseph P McEvoyTonmoy Sharma
Dec 2, 2006·The British Journal of Psychiatry : the Journal of Mental Science·Richard GrayMichele Tansella
Aug 10, 2007·The Journal of Clinical Psychiatry·Johannes HamannWerner Kissling
Sep 28, 2007·Psychiatry Research·R Walter HeinrichsStephanie McDermid Vaz
Oct 9, 2007·Schizophrenia Research·Filip SpanielCyril Höschl

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Citations

May 20, 2015·Journal of Child and Adolescent Psychiatric Nursing : Official Publication of the Association of Child and Adolescent Psychiatric Nurses, Inc·Masaharu NagaeHiroko Hanada
Aug 25, 2015·Journal of the American Academy of Child and Adolescent Psychiatry·David S Hong
Jul 18, 2016·Psychiatry Research·Jesus CoboAda I Ruiz
Oct 26, 2016·Revista de psiquiatrí́a y salud mental·Benedicto Crespo-FacorroCelso Arango
Feb 4, 2019·Acta Psychiatrica Scandinavica·J-G DaneaultJ L Shah
Jan 21, 2018·World Psychiatry : Official Journal of the World Psychiatric Association (WPA)·Paul H LysakerJenifer L Vohs
Nov 30, 2018·Frontiers in Psychiatry·Jaana SuvisaariTuukka T Raij
May 10, 2020·Indian Journal of Psychiatry·Dhanya RaveendranathanAshok Mysore
Oct 11, 2020·Early Intervention in Psychiatry·John F M GleesonMario Alvarez-Jimenez
Nov 11, 2020·European Archives of Psychiatry and Clinical Neuroscience·Hélène VerdouxNicolas Franck
Mar 2, 2021·The American Journal of Psychiatry·Margo D M Faay, Iris E Sommer
Feb 3, 2019·Schizophrenia Research·Donald C GoffJingping Zhao
Jul 27, 2021·Early Intervention in Psychiatry·Tze Kwan KamWing Chung Chang

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