Modeling dispersion of dry powders for inhalation. The concepts of total fines, cohesive energy and interaction parameters

International Journal of Pharmaceutics
Kyrre ThalbergMagnus Fransson

Abstract

A range of carrier based dry powder formulations consisting of micronized drug, carrier lactose and, in some formulations, lactose fines were produced and tested for dispersibility, i.e. fine particle fraction (FPF). Two different drugs were used, budesonide (BUD) and beclomethasone dipropionate (BDP). A model based on the total amount of fines (TF) and the cohesive energy (CE) of the formulation is proposed, where TF is the sum of added drug, lactose fines and the fines inherent to the carrier. The expression for CE is derived from regular solutions theory and allows calculation of interparticle interaction parameters. The model was able to describe experimental data well, such as the decrease in FPF when the proportion of drug is increased at a constant TF level and the non-linear effects seen when a cohesive drug is added to carrier. BDP and BUD were found to be 5.3 times and 1.8 times more cohesive than lactose fines respectively. The model hence provides a link between the macroscopic behavior of a dry powder formulation and the interaction between the different species at the particulate level.

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Citations

Mar 12, 2016·International Journal of Pharmaceutics·Kyrre ThalbergPatrik Andersson
May 20, 2015·International Journal of Pharmaceutics·Mireille HassounBen Forbes
Apr 20, 2016·Pharmaceutical Research·Bernice Mei Jin TanPaul Wan Sia Heng
Jan 13, 2015·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Duy NguyenKyrre Thalberg
Nov 13, 2012·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·S StegemannA Hincal
May 17, 2017·Journal of Aerosol Medicine and Pulmonary Drug Delivery·Tejal RawalShital Butani
Jun 3, 2017·Drug Development and Industrial Pharmacy·Saurabh SarkarBodhisattwa Chaudhuri
Jan 8, 2021·International Journal of Pharmaceutics: X·Jonas RudénGöran Alderborn
Dec 17, 2017·Journal of Pharmaceutical Sciences·Martin W JetzerGeorgios Imanidis
Mar 1, 2018·Molecular Pharmaceutics·Bernice Mei Jin TanPaul Wan Sia Heng
Nov 12, 2020·International Journal of Pharmaceutics·Kyrre ThalbergMark Nicholas

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