Modeling dissolution of sparingly soluble multisized powders

Journal of Pharmaceutical Sciences
L P de AlmeidaM Figueiredo

Abstract

The dissolution of powder drugs, besides being a topic of utmost importance, especially for the sparingly soluble ones, is far from being well-explained. The purpose of the present study is, on the one hand, to obtain experimental dissolution profiles and, on the other hand, to analyze and process the data for dissolution modeling. Three different size fractions of a widely used sparingly soluble drug--ibuprofen--were fully characterized with regard to its particle size distribution, specific surface area, density, solubility, and diffusion coefficient. The dissolution profiles were obtained making use of a technique that counts and sizes particles--the Coulter counter technique--which is capable of following the number and size of the particles in suspension throughout time. The knowledge of these parameters allowed a critical study of the assumptions associated with the models currently used to describe the dissolution process. It was concluded that most of the assumptions were not valid for the present experimental conditions. This motivated the proposal of a new methodology, which uses the experimentally determined characteristics of the drug and takes into account the polydisperse nature of the powder. By applying an adequ...Continue Reading

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Citations

Nov 3, 2009·Biological & Pharmaceutical Bulletin·Ryusuke TakanoShinji Yamashita
Apr 9, 2001·Drug Development and Industrial Pharmacy·M H AmaralD C Ferreira
Jul 7, 1999·Journal of Pharmaceutical Sciences·J Wang, D R Flanagan
Feb 9, 2002·Journal of Pharmaceutical Sciences·Jianzhuo Wang, Douglas R Flanagan
Dec 27, 2011·Journal of Pharmaceutical and Biomedical Analysis·Fengbin YeJesper Østergaard
Jul 15, 2015·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Raphael PausYuanhui Ji
Mar 10, 2015·International Journal of Pharmaceutics·Raphael PausYuanhui Ji
Feb 27, 2015·Pharmaceutical Research·Yuanhui JiGabriele Sadowski
Nov 26, 2009·Chemistry & Biodiversity·Alex AvdeefDmytro Voloboy
Jun 12, 2014·Environmental Science & Technology·Tiezheng TongJean-François Gaillard

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