Modeling DNA condensation on freestanding cationic lipid membranes

Physical Chemistry Chemical Physics : PCCP
A G Cherstvy, E P Petrov

Abstract

Motivated by recent experimental observations of a rapid spontaneous DNA coil-globule transition on freestanding cationic lipid bilayers, we propose simple theoretical models for DNA condensation on cationic lipid membranes. First, for a single DNA rod, we examine the conditions of full wrapping of a cylindrical DNA-like semi-flexible polyelectrolyte by an oppositely charged membrane. Then, for two parallel DNA rods, we self-consistently analyze the shape and the extent of the membrane enveloping them, focusing on membrane elastic deformations and the membrane-DNA embracing angle, which enables us to compute the membrane-mediated DNA-DNA interactions. We examine the effects of the membrane composition and its charge density, which are the experimentally tunable parameters. We show that membrane-driven rod-rod attraction is more pronounced for higher charge densities and for smaller surface tensions of the membrane. Thus, we demonstrate that for a long DNA chain adhered to a cationic lipid membrane, such membrane-induced DNA-DNA attraction can trigger compaction of DNA.

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Citations

Apr 15, 2014·The Journal of Physical Chemistry. B·Andrey G Cherstvy
Jun 24, 2014·Physical Chemistry Chemical Physics : PCCP·Sidney J de CarvalhoAndrey G Cherstvy
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Jul 15, 2017·The Journal of Physical Chemistry. B·Andrey G Cherstvy
Nov 15, 2018·Physical Chemistry Chemical Physics : PCCP·Beibei HuangShuxing Zhang
Jan 25, 2019·Physical Chemistry Chemical Physics : PCCP·Kang-Tao Liu, Shi-Yong Ran
May 31, 2019·Physical Chemistry Chemical Physics : PCCP·Daniel G Angelescu
Jun 24, 2020·Journal of the Royal Society, Interface·Daniel L Z CaetanoAndrey G Cherstvy
Mar 4, 2021·International Journal of Molecular Sciences·Tomoki KitagawaKenichi Yoshikawa
Apr 28, 2021·Physical Chemistry Chemical Physics : PCCP·Yoko IkedaSatoru Watano
May 14, 2021·Langmuir : the ACS Journal of Surfaces and Colloids·Sarah E Zuraw-WestonAnthony D Dinsmore
Jul 10, 2021·The Journal of Chemical Physics·Antonio LamuraGerhard Gompper

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