Modeling Edar expression reveals the hidden dynamics of tooth signaling center patterning

PLoS Biology
Alexa SadierSophie Pantalacci

Abstract

When patterns are set during embryogenesis, it is expected that they are straightly established rather than subsequently modified. The patterning of the three mouse molars is, however, far from straight, likely as a result of mouse evolutionary history. The first-formed tooth signaling centers, called MS and R2, disappear before driving tooth formation and are thought to be vestiges of the premolars found in mouse ancestors. Moreover, the mature signaling center of the first molar (M1) is formed from the fusion of two signaling centers (R2 and early M1). Here, we report that broad activation of Edar expression precedes its spatial restriction to tooth signaling centers. This reveals a hidden two-step patterning process for tooth signaling centers, which was modeled with a single activator-inhibitor pair subject to reaction-diffusion (RD). The study of Edar expression also unveiled successive phases of signaling center formation, erasing, recovering, and fusion. Our model, in which R2 signaling center is not intrinsically defective but erased by the broad activation preceding M1 signaling center formation, predicted the surprising rescue of R2 in Edar mutant mice, where activation is reduced. The importance of this R2-M1 interac...Continue Reading

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Citations

Apr 27, 2019·PLoS Neglected Tropical Diseases·Julien GuglielminiMathieu Picardeau
Oct 7, 2019·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Juan M FonsAbigail S Tucker
Feb 13, 2020·ELife·Luke HaydenSophie Pantalacci
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Mar 27, 2020·ELife·Charles C Roseman
Aug 8, 2020·Integrative and Comparative Biology·Alexa SadierKaren E Sears
Nov 4, 2020·Journal of Molecular Histology·Jung-Sun MoonSun-Hun Kim
Jan 29, 2021·Frontiers in Cell and Developmental Biology·Vladimír SoukupRobert Cerny
Feb 3, 2021·Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution·Alexa SadierMolly Womack
Mar 5, 2021·Frontiers in Cell and Developmental Biology·Eun-Jung KimHan-Sung Jung
Oct 9, 2019·Archives of Oral Biology·Ludivine Bertonnier-BroutyCyril Charles
Dec 24, 2020·Molecular Biology and Evolution·Manuel Jara-EspejoSergio Roberto Peres Line

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Methods Mentioned

BETA
dissection

Software Mentioned

MT
matlab
Edar
teethsolver

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