Modeling energy deposition and cellular radiation effects in human bronchial epithelium by radon progeny alpha particles

Health Physics
W HofmannL R Karam

Abstract

Energy deposition and cellular radiation effects arising from the interaction of single 218Po and 214Po alpha particles with basal and secretory cell nuclei were simulated for different target cell depths in the bronchial epithelium of human airway generations 2, 4, 6, and 10. To relate the random chord lengths of alpha particle tracks through spherical cell nuclei to the resulting biological endpoints, probabilities per unit track length for different cellular radiation effects as functions of LET were derived from in vitro experiments. The radiobiological data employed in the present study were inactivation and mutation (mutant frequency at the HPRT gene) in V79 Chinese hamster cells and inactivation and transformation in C3H 10T1/2 cells. Based on computed LET spectra and relative frequencies of target cells, probabilities for transformation, mutation, and cell killing in basal and secretory cells were computed for a lifetime exposure of 20 WLM. While predicted transformation probabilities were about two orders of magnitude higher than mutation probabilities, they were still about two orders of magnitude lower than inactivation probabilities. Furthermore transformation probabilities for basal cells are generally higher than ...Continue Reading

References

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Citations

Sep 22, 2009·Radiation Protection Dosimetry·Paul F BaiasOctavian G Duliu
May 16, 2003·Health Physics·D Nikezic, K N Yu
Nov 4, 2009·Radiation Research·Giuseppe EspositoMaria Antonella Tabocchini
Mar 1, 2015·Radiation and Environmental Biophysics·R Winkler-HeilWerner Hofmann
Jan 13, 2005·Radiation Protection Dosimetry·H FakirI Aubineau-Laniece
Jun 24, 2005·Radiation Protection Dosimetry·H FakirI Aubineau-Laniece
Apr 26, 2020·International Journal of Environmental Research and Public Health·W S KwanK N Yu
Jan 11, 2007·Radiation Protection Dosimetry·B M F LauK N Yu
Aug 14, 2019·Risk Analysis : an Official Publication of the Society for Risk Analysis·Radoslav BöhmKarol Holý
Dec 22, 2019·Radiation and Environmental Biophysics·Werner HofmannImre Balásházy
Jul 28, 2001·Physics in Medicine and Biology·D NikezicD Vucic

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Metazoa
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