Modeling epistasis of quantitative trait loci using Cockerham's model.

Genetics
Chen-Hung Kao, Zhao-Bang Zeng

Abstract

We use the orthogonal contrast scales proposed by Cockerham to construct a genetic model, called Cockerham's model, for studying epistasis between genes. The properties of Cockerham's model in modeling and mapping epistatic genes under linkage equilibrium and disequilibrium are investigated and discussed. Because of its orthogonal property, Cockerham's model has several advantages in partitioning genetic variance into components, interpreting and estimating gene effects, and application to quantitative trait loci (QTL) mapping when compared to other models, and thus it can facilitate the study of epistasis between genes and be readily used in QTL mapping. The issues of QTL mapping with epistasis are also addressed. Real and simulated examples are used to illustrate Cockerham's model, compare different models, and map for epistatic QTL. Finally, we extend Cockerham's model to multiple loci and discuss its applications to QTL mapping.

References

Mar 1, 1995·Genetics·J M Cheverud, E J Routman
Apr 1, 1994·Genetics·Z B Zeng
Jul 1, 1996·Genetics·C C Cockerham, Z B Zeng
Jul 2, 1999·Genetics·C H KaoR D Teasdale
Sep 19, 2001·Genetics·S Sen, G A Churchill
Sep 1, 1980·Evolution; International Journal of Organic Evolution·Sewall Wright

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Citations

Oct 10, 2006·Genetics·Arne B GjuvslandOrjan Carlborg
Aug 28, 2007·Genetics·Zaixiang TangChenwu Xu
Sep 5, 2002·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Tanya M GottliebSuzanne L Rutherford
May 11, 2005·Genetica·Patrick C Phillips
May 11, 2005·Journal of Theoretical Biology·Phil Hanlon, Andy Lorenz
Dec 16, 2006·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·Xing-You Gu, Michael E Foley
Aug 12, 2008·Genetics·Samprit BanerjeeNengjun Yi
Aug 20, 2008·Genetics·Xing-You GuMichael E Foley
Apr 21, 2006·Genetics·Andreas BaierlAndreas Futschik
Jun 5, 2003·Evolution; International Journal of Organic Evolution·Yamama Naciri-Graven, Jérôme Goudet
Dec 5, 2003·American Journal of Human Genetics·Martin Farrall
Jun 20, 2006·Physiological Genomics·Philip HanlonDavid T Burke
Jan 18, 2005·Genetics·Zhao-Bang ZengWei Zou
May 23, 2007·Journal of Dairy Science·J Szyda, J Komisarek
Feb 16, 2005·Functional & Integrative Genomics·Pawan KulwalPushpendra Kumar Gupta
May 3, 2008·PLoS Genetics·José M Alvarez-CastroOrjan Carlborg

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