Apr 10, 2020

AGE DEPENDENT EFFECTS OF PROTEIN RESTRICTION ON DOPAMINE RELEASE

BioRxiv : the Preprint Server for Biology
Fabien NaneixJ. E. McCutcheon

Abstract

Despite the essential role of protein intake for health and development, very little is known about the impact of protein restriction on neurobiological functions, especially at different stages of the lifespan. The dopamine system is a central actor in the integration of food-related processes and is influenced by physiological state and food-related signals. Moreover, it is highly sensitive to dietary effects during early life periods such as adolescence due to its late maturation. In the present study, we investigated the impact of protein restriction either during adolescence or adulthood on the function of the mesolimbic (nucleus accumbens) and nigrostriatal (dorsal striatum) dopamine pathways using fast-scan cyclic voltammetry in rat brain slices. In the nucleus accumbens, protein restriction in adults increased dopamine release in response to high frequency trains of stimulation (10-20 Hz) with no effect on single pulse evoked release. By contrast, protein restriction performed at adolescence decreased nucleus accumbens dopamine release evoked by both single pulses and trains of stimulation pulses (5-10 Hz). In the dorsal striatum, protein restriction has no impact on dopamine release when performed at adulthood but in a...Continue Reading

  • References
  • Citations

References

  • We're still populating references for this paper, please check back later.
  • References
  • Citations

Citations

  • This paper may not have been cited yet.

Mentioned in this Paper

Assay
Dispense
Dilution Technique
Robotic Surgical Systems

Related Feeds

BioRxiv & MedRxiv Preprints

BioRxiv and MedRxiv are the preprint servers for biology and health sciences respectively, operated by Cold Spring Harbor Laboratory. Here are the latest preprint articles (which are not peer-reviewed) from BioRxiv and MedRxiv.