Modeling familial British dementia in transgenic mice.

Brain Pathology
Fiona PickfordEileen McGowan

Abstract

The chromosome 13 linked amyloidopathies familial British dementia (FBD) and familial Danish dementia (FDD) are caused by mutations in the C-terminus of the BRI2 gene. In both diseases, novel peptides are deposited in amyloid plaques in the brain. Several laboratories have attempted to model these diseases in BRI2 transgenic mice with limited success. While high expression levels of BRI protein were achieved in transgenic lines, no ABri-amyloidosis was observed in aged mice. This review discusses the strategies chosen and problems experienced with the development of FBD/FDD models and suggests novel approaches to model the diseases in murine models.

References

Oct 13, 1992·Annals of the New York Academy of Sciences·W H VelanderJ L Johnson
Nov 7, 1995·Proceedings of the National Academy of Sciences of the United States of America·R DrewsH Luboń
Dec 1, 1996·Genetic Analysis : Biomolecular Engineering·D R BorcheltD L Price
Jun 13, 1997·The Journal of Biological Chemistry·R K PaleyandaH Luboń
Dec 16, 1997·Proceedings of the National Academy of Sciences of the United States of America·C Sturchler-PierratB Sommer
Oct 28, 1999·Neurobiology of Aging·S Y Guénette, R E Tanzi
Nov 26, 1999·Proceedings of the National Academy of Sciences of the United States of America·M E CalhounM Jucker
Oct 13, 2001·Trends in Molecular Medicine·M HuttonE McGowan
Oct 3, 2002·Nature Reviews. Molecular Cell Biology·Gary Thomas
Nov 6, 2002·Human Molecular Genetics·Stacie K LoftusWilliam J Pavan
Feb 5, 2003·Neuroscience Letters·Fiona PickfordEileen McGowan
May 20, 2003·CNS Drugs·Christopher Janus
Sep 25, 2003·Neurological Research·Amie L PhinneyDavid Westaway
Oct 3, 2003·British Medical Bulletin·C Weissmann, E Flechsig
Oct 30, 2003·Journal of Molecular Biology·Rekha SrinivasanMichael G Zagorski

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Citations

Sep 26, 2009·Brain Structure & Function·Holly J GarringerRuben Vidal
Nov 20, 2009·PloS One·Luca GilibertoLuciano D'Adamio
Aug 30, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Shuji MatsudaLuciano D'Adamio
May 24, 2012·Journal of Biomedicine & Biotechnology·Monica VitaleNicola Zambrano
Apr 14, 2010·Proceedings of the National Academy of Sciences of the United States of America·Janaky CoomaraswamyMathias Jucker
Dec 17, 2008·Biotechnology Journal·Maria TsachakiSpiros Efthimiopoulos
Apr 15, 2006·Brain Pathology·Roberto Alvarez-LafuenteRafael Arroyo

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