Modeling framework for the establishment of the apical-basal embryonic axis in plants

Current Biology : CB
Krzysztof WabnikJirí Friml

Abstract

The apical-basal axis of the early plant embryo determines the body plan of the adult organism. To establish a polarized embryonic axis, plants evolved a unique mechanism that involves directional, cell-to-cell transport of the growth regulator auxin. Auxin transport relies on PIN auxin transporters, whose polar subcellular localization determines the flow directionality. PIN-mediated auxin transport mediates the spatial and temporal activity of the auxin response machinery that contributes to embryo patterning processes, including establishment of the apical (shoot) and basal (root) embryo poles. However, little is known of upstream mechanisms guiding the (re)polarization of auxin fluxes during embryogenesis. Here, we developed a model of plant embryogenesis that correctly generates emergent cell polarities and auxin-mediated sequential initiation of apical-basal axis of plant embryo. The model relies on two precisely localized auxin sources and a feedback between auxin and the polar, subcellular PIN transporter localization. Simulations reproduced PIN polarity and auxin distribution, as well as previously unknown polarization events during early embryogenesis. The spectrum of validated model predictions suggests that our mode...Continue Reading

References

Jan 5, 2001·Circulation Research·D H Gorski, K Walsh
Feb 13, 2001·Current Opinion in Plant Biology·Thomas Berleth, T Sachs
Nov 14, 2003·Nature·Stefan Kepinski, Ottoline Leyser
Oct 18, 2006·Genes & Development·Michael SauerEva Benková
Oct 14, 2008·Proceedings of the National Academy of Sciences of the United States of America·Gang WuRandall A Kerstetter
Dec 19, 2008·PLoS Biology·Richard S Smith
Feb 11, 2009·Genes & Development·Emmanuelle M BayerCris Kuhlemeier
Apr 24, 2009·Trends in Plant Science·Eric M Kramer
Aug 19, 2009·Annual Review of Genetics·Elisabeth J Chapman, Mark Estelle
Oct 7, 2009·Proceedings of the National Academy of Sciences of the United States of America·Przemyslaw PrusinkiewiczOttoline Leyser
Dec 24, 2010·Molecular Systems Biology·Krzysztof WabnikJirí Friml
Mar 3, 2011·Nature Reviews. Molecular Cell Biology·Adrienne H K RoederElliot M Meyerowitz
Oct 18, 2011·Current Opinion in Plant Biology·Henrik JönssonCarl Troein
Jan 13, 2012·The New Phytologist·Przemyslaw Prusinkiewicz, Adam Runions
Jan 24, 2012·Developmental Cell·Eike H RademacherDolf Weijers
Jun 26, 2012·The Plant Cell·Laurent GutierrezCatherine Bellini
Aug 21, 2013·Nature Reviews. Genetics·Erin SparksPhilip N Benfey
Dec 3, 2013·Current Biology : CB·Helene S RobertJirí Friml

Citations

Dec 4, 2014·Proceedings of the National Academy of Sciences of the United States of America·Ora HazakShaul Yalovsky
Oct 27, 2015·Current Opinion in Plant Biology·Margot E Smit, Dolf Weijers
Aug 8, 2015·Current Opinion in Plant Biology·Cyril LavedrineTeva Vernoux
Feb 6, 2014·Physiologia Plantarum·Tatsuaki GohAnthony Bishopp
Apr 26, 2015·Journal of Experimental Botany·L TurchiI Ruberti
May 7, 2015·ELife·Pierre Barbier de ReuilleRichard S Smith
Dec 3, 2013·Current Biology : CB·Helene S RobertJirí Friml
Apr 9, 2015·Frontiers in Plant Science·Eric M Kramer, Ethan M Ackelsberg
Feb 7, 2015·Plant Reproduction·Gregorio Orozco-ArroyoLucia Colombo
Jul 30, 2014·Frontiers in Plant Science·Natalie M ClarkRosangela Sozzani
Sep 10, 2014·Frontiers in Plant Science·Antonella LocascioSerena Varotto
May 22, 2016·Developmental Biology·Sangho JeongWolfgang Lukowitz
Aug 2, 2016·ELife·Katie AbleyEnrico Coen
Sep 1, 2016·Annual Review of Cell and Developmental Biology·Joakim PalovaaraDolf Weijers
Dec 2, 2017·International Journal of Molecular Sciences·Damilola OlatunjiInge Verstraeten
May 14, 2018·Plant Biotechnology Journal·Jiao XuXianlong Zhang
Jul 4, 2018·Development·Markéta PernisováJan Hejatko
Jun 1, 2014·American Journal of Botany·Gar W RothwellAlexandru M F Tomescu
Aug 6, 2017·Botanical Studies·Edward C Yeung
Dec 21, 2017·International Journal of Molecular Sciences·Barbora PařízkováOndrej Novak
Jul 18, 2018·Nature Plants·Helene S RobertThomas Laux
Dec 11, 2019·International Journal of Molecular Sciences·Abu Imran BabaÁgnes Cséplő
Feb 5, 2021·Proceedings of the National Academy of Sciences of the United States of America·Min ChenRobert B Goldberg
Jan 13, 2021·Cold Spring Harbor Perspectives in Biology·Rubén Casanova-SáezKarin Ljung
Jan 22, 2015·Development·Colette A ten HoveDolf Weijers
Jan 27, 2015·Development·Helene S RobertJirí Friml
Mar 18, 2021·Plant Physiology·Madhumitha NarasimhanJirí Friml

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Hereditary Sensory Autonomic Neuropathy

Hereditary Sensory Autonomic Neuropathies are a group of inherited neurodegenerative disorders characterized clinically by loss of sensation and autonomic dysfunction. Here is the latest research on these neuropathies.

Spatio-Temporal Regulation of DNA Repair

DNA repair is a complex process regulated by several different classes of enzymes, including ligases, endonucleases, and polymerases. This feed focuses on the spatial and temporal regulation that accompanies DNA damage signaling and repair enzymes and processes.

Glut1 Deficiency

Glut1 deficiency, an autosomal dominant, genetic metabolic disorder associated with a deficiency of GLUT1, the protein that transports glucose across the blood brain barrier, is characterized by mental and motor developmental delays and infantile seizures. Follow the latest research on Glut1 deficiency with this feed.

Separation Anxiety

Separation anxiety is a type of anxiety disorder that involves excessive distress and anxiety with separation. This may include separation from places or people to which they have a strong emotional connection with. It often affects children more than adults. Here is the latest research on separation anxiety.

KIF1A Associated Neurological Disorder

KIF1A associated neurological disorder (KAND) is a rare neurodegenerative condition caused by mutations in the KIF1A gene. KAND may present with a wide range and severity of symptoms including stiff or weak leg muscles, low muscle tone, a lack of muscle coordination and balance, and intellectual disability. Find the latest research on KAND here.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.