Modeling glucose and water dynamics in human skin

Diabetes Technology & Therapeutics
W GroenendaalPeter A J Hilbers

Abstract

Glucose is heterogeneously distributed in the different physiological compartments in the human skin. Therefore, for the development of a noninvasive measurement method, both a good quantification of the different compartments of human skin and an understanding of glucose transport processes are important. The composition of human skin was quantified by histology research. Based on this information a mathematical model was developed to simulate glucose dynamics in human skin. The model predicts dynamically glucose concentrations in the different layers of the skin as a result of changes in blood glucose concentration. The model was validated with published time course data of blood and interstitial fluid glucose during a clamp study with three different set points for blood glucose, and model outcomes were compared to measurements for the lag time and gradient. According to the model, glucose in the interstitial fluid of the dermis best matches the amplitude and dynamics of blood glucose. The new data obtained from quantitative histology appeared crucial for the model. The proposed model was successfully validated. This result was obtained without tuning or fitting of any parameter. It was shown how the model can be used to set...Continue Reading

References

Jun 1, 1979·The American Journal of Physiology·R N BergmanC Cobelli
Dec 1, 1977·Circulation Research·E M Renkin
Jan 1, 1976·Microvascular Research·E P Salathe, K N An
Feb 17, 1992·Biochimica Et Biophysica Acta·N LongoL J Elsas
Jul 1, 1989·Metabolism: Clinical and Experimental·N LongoL J Elsas
Feb 1, 1988·The Journal of Investigative Dermatology·R R WarnerD A Taylor
Feb 1, 1988·The American Journal of Physiology·J L BertR K Reed
Dec 1, 1966·Respiration Physiology·N T Evans, P F Naylor
Jun 1, 1967·The Journal of Clinical Investigation·E A RasioG F Cahill
Jan 1, 1994·Skin Pharmacology : the Official Journal of the Skin Pharmacology Society·B QuerleuxJ L Lévêque
Jan 1, 1993·Physiological Reviews·K Aukland, R K Reed
Jun 1, 1996·The British Journal of Dermatology·A L KrogstadP Lönnroth
Mar 10, 1999·The American Journal of Physiology·K Zierler
Mar 17, 1999·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·K ThomasW Kerner
Jul 3, 1999·Physiological Reviews·C C Michel, F E Curry
Sep 14, 1999·The American Journal of Physiology·K RebrinJ J Mastrototaro
Apr 15, 2000·The American Journal of Medicine·S E Kahn
Mar 10, 2001·Recent Progress in Hormone Research·R T Watson, J E Pessin
Mar 22, 2001·Advanced Drug Delivery Reviews·M J Pikal
Apr 6, 2002·American Journal of Physiology. Endocrinology and Metabolism·Patricia IozzoPaolo G Camici
Nov 27, 2002·Diabetes Technology & Therapeutics·Lutz Heinemann
Apr 10, 2003·American Journal of Physiology. Endocrinology and Metabolism·Werner RegittnigThomas R Pieber
Apr 24, 2003·Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·Jouni NuutinenTapani Lahtinen
Jun 28, 2003·Biophysical Journal·P J CaspersG J Puppels
Oct 29, 2003·The Journal of Cell Biology·Michael S Pepper, Mihaela Skobe
Apr 3, 2004·Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·Patricia M van KemenadeLucien F A Douven
Oct 12, 2004·American Journal of Physiology. Heart and Circulatory Physiology·C C Michel
Dec 31, 2004·Lymphatic Research and Biology·Waldemar L Olszewski
Mar 2, 2005·Diabetes Technology & Therapeutics·Ping M WangMark R Prausnitz
Mar 29, 2005·Environmental Technology·T Zhang, H H P Fang

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Citations

Jul 21, 2009·Diabetes Technology & Therapeutics·Eda Cengiz, William V Tamborlane
Feb 22, 2014·BMC Systems Biology·Joep VanlierNatal A W van Riel
Feb 17, 2009·Diabetes/metabolism Research and Reviews
May 11, 2012·Biomedical Optics Express·Jonas KottmannMarkus W Sigrist
Mar 29, 2013·Mathematical Biosciences·J VanlierN A W van Riel
Feb 11, 2010·Journal of Diabetes Science and Technology·Jan LipsonUNKNOWN C8 MediSensors,
Oct 6, 2010·Journal of Diabetes Science and Technology·Willemijn GroenendaalNatal A W van Riel
Oct 6, 2010·Journal of Diabetes Science and Technology·Natalia V Alexeeva, Mark A Arnold
Jan 9, 2013·Journal of Diabetes Science and Technology·Cosimo ScuffiFrancesco Valgimigli
Oct 3, 2018·Journal of Pharmaceutical Sciences·Terri D La CountGerald B Kasting
Feb 11, 2021·Animals : an Open Access Journal From MDPI·Francesca Del BaldoFederico Fracassi
Sep 4, 2021·Journal of Theoretical Biology·Alejandro Herron-BedoyaHernan Alvarez

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