Modeling glucose metabolism and lactate production in the kidney

Mathematical Biosciences
Ying ChenAnita T Layton

Abstract

The metabolism of glucose provides most of the ATP required for energy-dependent transport processes. In the inner medulla of the mammalian kidney, limited blood flow and O2 supply yield low oxygen tension; therefore, a substantial fraction of the glucose metabolism in that region is anaerobic. Lactate is considered to be a waste product of anaerobic glycolysis, which yields two lactate molecules for each glucose molecule consumed, thereby likely leading to the production and accumulation of a significant amount of lactate in the inner medulla. To gain insights into the transport and metabolic processes in the kidney, we have developed a detailed mathematical model of the renal medulla of the rat kidney. The model represents the radial organization of the renal tubules and vessels, which centers around the vascular bundles in the outer medulla and around clusters of collecting ducts in the inner medulla. Model simulations yield significant radial gradients in interstitial fluid oxygen tension and glucose and lactate concentrations in the outer medulla and upper inner medulla. In the deep inner medulla, interstitial fluid concentrations become much more homogeneous, as the radial organization of tubules and vessels is not distin...Continue Reading

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Citations

Mar 6, 2019·Metabolomics : Official Journal of the Metabolomic Society·Marina Mora-OrtizSandrine P Claus
Jul 28, 2019·Acta Physiologica·Nikolaus BerndtHermann-Georg Holzhütter
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Apr 3, 2020·Seminars in Pediatric Surgery·Petter BjornstadDaniel van Raalte
Mar 27, 2021·Nature Reviews. Nephrology·Sébastien J DumasPeter Carmeliet
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Jul 31, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Meiwen DingNisanne S Ghonem
Aug 31, 2021·American Journal of Physiology. Renal Physiology·David Sheikh-Hamad

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