Modeling Human Cancer-induced Cachexia.

Cell Reports
Erin E TalbertDenis C Guttridge

Abstract

Cachexia is a wasting syndrome characterized by pronounced skeletal muscle loss. In cancer, cachexia is associated with increased morbidity and mortality and decreased treatment tolerance. Although advances have been made in understanding the mechanisms of cachexia, translating these advances to the clinic has been challenging. One reason for this shortcoming may be the current animal models, which fail to fully recapitulate the etiology of human cancer-induced tissue wasting. Because pancreatic ductal adenocarcinoma (PDA) presents with a high incidence of cachexia, we engineered a mouse model of PDA that we named KPP. KPP mice, similar to PDA patients, progressively lose skeletal and adipose mass as a consequence of their tumors. In addition, KPP muscles exhibit a similar gene ontology as cachectic patients. We envision that the KPP model will be a useful resource for advancing our mechanistic understanding and ability to treat cancer cachexia.

Citations

Dec 4, 2019·The Journal of Clinical Investigation·Ines BoehmThomas H Gillingwater
Feb 11, 2020·Journal of Cachexia, Sarcopenia and Muscle·Rachel L NosackaAndrew R Judge
Feb 14, 2020·Expert Opinion on Drug Discovery·Tsuyoshi SuzukiJochen Springer
Jul 7, 2020·Journal of Cellular and Molecular Medicine·Luise EhlersRobert Jaster
Sep 15, 2020·Journal of Cachexia, Sarcopenia and Muscle·Barbara BernardoDanna M Breen
Feb 13, 2020·Journal of Cachexia, Sarcopenia and Muscle·Nicole EbnerStephan von Haehling
Mar 3, 2020·Frontiers in Cell and Developmental Biology·Xiaoting SunYing Ye
Nov 15, 2019·Journal of Applied Physiology·Megan E Rosa-CaldwellNicholas P Greene
Jul 28, 2020·International Journal of Molecular Sciences·Sara Peixoto da SilvaRui Medeiros
Mar 15, 2020·Physiological Reports·Angela C GreenmanGary M Diffee
Oct 14, 2020·Journal of Cachexia, Sarcopenia and Muscle·Rianne D W VaesSander S Rensen
Dec 3, 2020·Current Protocols in Pharmacology·Spas Dimitrov MarkovKamiya Mehla
Feb 3, 2021·Journal of Cachexia, Sarcopenia and Muscle·Daria NeyroudAndrew R Judge
Dec 18, 2020·Frontiers in Oncology·Gioacchino P MarcecaCarlo M Croce
Jan 16, 2021·Diagnostics·Emanuele BerardiDario Coletti
Mar 21, 2021·British Journal of Cancer·Maximilian KordesJ-Matthias Löhr
Mar 31, 2021·Journal of Cachexia, Sarcopenia and Muscle·Agnès Martin, Damien Freyssenet
Apr 26, 2021·Advanced Drug Delivery Reviews·Marcel A HeinrichJai Prakash
Jul 29, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Lijuan HuFeng Wang
Aug 6, 2021·Science Translational Medicine·Roberta SartoriMarco Sandri
Jul 31, 2021·The British Journal of Nutrition·Yi-Zhong GeHan-Ping Shi
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Nov 7, 2021·Journal of Cachexia, Sarcopenia and Muscle·Alessia GeremiaBert Blaauw

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Datasets Mentioned

BETA
GSE133523
GSE133524

Methods Mentioned

BETA
xenograft
biopsies
RNA-seq
chip
PCR

Software Mentioned

ImageJ
Morpheus
ToppGene Suite
featureCounts
ToppFun
tophat2v2
limma
GraphPad Prism
ensembl
HISAT2

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