Modeling Human Ductal Carcinoma In Situ in the Mouse.

Journal of Mammary Gland Biology and Neoplasia
Fariba BehbodHeather L Machado

Abstract

Breast cancer development is a multi-step process in which genetic and molecular heterogeneity occurs at multiple stages. Ductal carcinoma arises from pre-invasive lesions such as atypical ductal hyperplasia (ADH) and ductal carcinoma in situ (DCIS), which progress to invasive and metastatic cancer. The feasibility of obtaining tissue samples from all stages of progression from the same patient is low, and thus molecular studies dissecting the mechanisms that mediate the transition from pre-invasive DCIS to invasive carcinoma have been hampered. In the past 25 years, numerous mouse models have been developed that partly recapitulate the histological and biological properties of early stage lesions. In this review, we discuss in vivo model systems of breast cancer progression from syngeneic mouse models to human xenografts, with particular focus on how accurately these models mimic human disease.

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Citations

Jan 8, 2020·Journal of Cellular Biochemistry·Rebecca S DeVauxJason I Herschkowitz
May 1, 2020·NPJ Breast Cancer·Hanan S ElsarrajFariba Behbod
Dec 12, 2018·Oncogene·Angelica M GomesHeather L Machado
Aug 28, 2019·Molecular Cancer Therapeutics·William B KietzmanAnna T Riegel
Feb 13, 2021·NPJ Breast Cancer·Hanan S ElsarrajFariba Behbod

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Methods Mentioned

BETA
transgenic
xenograft
laser capture microcopy
biopsy
xenografts
SMA
laser capture microdissection

Software Mentioned

MIND

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