Abstract
Type I hypersensitivity, which functions to protect the organism from parasites, is caused by binding of antigen to IgE antibodies pre-attached to the cell surface of tissue mast cells and their circulating counterparts, the basophils. In "allergy," type I hypersensitivity is inappropriately induced by protein-based foreign substances (such as pollen) or protein components of insect stings, which in the normal course of events would be cleared from the organism without causing any damage. Paradoxically, a successful clinical treatment of allergy involves repeated immunization of allergic persons with low doses of the allergen--immunotherapy. Investigation of the available experimental evidence leads to the conclusion that the phenomena of immunotherapy are best addressed in terms of the interplay among the mechanism(s) of immune memory--Th1/Th2 cross-regulation--and the physical compartmentalization of the immune system. These conclusions are illustrated with a numerical simulation.
References
Jan 1, 1976·Advances in Immunology·K Ishizaka
Mar 1, 1991·Immunology Today·T R Mosmann, K W Moore
Dec 1, 1989·The Journal of Experimental Medicine·D F FiorentinoT R Mosmann
Aug 1, 1988·The Journal of Experimental Medicine·R Fernandez-BotranE S Vitetta
Jan 1, 1987·Annual Review of Immunology·J J WoodruffY H Chin
Aug 1, 1987·The Journal of Allergy and Clinical Immunology·D F GraftM D Valentine
May 1, 1982·The Journal of Experimental Medicine·D G MarshW B Bias
Jan 1, 1980·Immunological Reviews·J G TewT E Mandel
May 1, 1980·Annals of Internal Medicine·D B GoldenL M Lichtenstein
Nov 1, 1995·Immunity·M DaëronW H Fridman
Nov 1, 1995·The Journal of Experimental Medicine·N A HoskenA O'Garra
Apr 7, 1995·Journal of Theoretical Biology·M A Fishman, A S Perelson
Dec 1, 1993·The Journal of Experimental Medicine·H SecristD T Umetsu
Jan 1, 1994·Annual Review of Immunology·R A Seder, W E Paul
Sep 7, 1994·Journal of Theoretical Biology·M A Fishman, A S Perelson
Feb 7, 1993·Journal of Theoretical Biology·M A Fishman, A S Perelson
Jan 1, 1993·Advances in Immunology·G KroemerC Martínez
Nov 1, 1995·Parasite Immunology·G S NaborsJ P Farrell
Citations
Sep 22, 2007·Bulletin of Mathematical Biology·M A Fishman, A S Perelson
Feb 1, 2000·Mathematical Biosciences·R L Bar-Or
Dec 5, 2006·Expert Review of Molecular Diagnostics·Heike E AssmusOlaf Wolkenhauer