Modeling influenza seasonality in the tropics and subtropics.

PLoS Computational Biology
H. YuanWan Yang

Abstract

Climate drivers such as humidity and temperature may play a key role in influenza seasonal transmission dynamics. Such a relationship has been well defined for temperate regions. However, to date no models capable of capturing the diverse seasonal pattern in tropical and subtropical climates exist. In addition, multiple influenza viruses could cocirculate and shape epidemic dynamics. Here we construct seven mechanistic epidemic models to test the effect of two major climate drivers (humidity and temperature) and multi-strain co-circulation on influenza transmission in Hong Kong, an influenza epidemic center located in the subtropics. Based on model fit to long-term influenza surveillance data from 1998 to 2018, we found that a simple model incorporating the effect of both humidity and temperature best recreated the influenza epidemic patterns observed in Hong Kong. The model quantifies a bimodal effect of absolute humidity on influenza transmission where both low and very high humidity levels facilitate transmission quadratically; the model also quantifies the monotonic but nonlinear relationship with temperature. In addition, model results suggest that, at the population level, a shorter immunity period can approximate the co-...Continue Reading

References

Jan 1, 1983·Annual Review of Microbiology·R B Couch, J A Kasel
May 22, 2003·Paediatric Respiratory Reviews·Lynette Pei-Chi Shek, Bee-Wah Lee
Dec 1, 1961·The Journal of Hygiene·G J HARPER
Jun 26, 2004·Science·Derek J SmithRon A M Fouchier
Dec 17, 2004·Nature·Christina E MillsMarc Lipsitch
Jan 6, 2006·American Journal of Epidemiology·Sharon K GreeneMark L Wilson
Mar 7, 2006·PLoS Medicine·Chit Ming WongJoseph S M Peiris
Aug 28, 2007·Vaccine·F Carrat, A Flahault
Oct 24, 2007·PLoS Pathogens·Anice C LowenPeter Palese
Dec 17, 2008·Veterinary Microbiology·Justin D BrownDavid E Stallknecht
Feb 11, 2009·Proceedings of the National Academy of Sciences of the United States of America·Jeffrey Shaman, Melvin Kohn
Nov 26, 2010·Environmental Health Perspectives·James TameriusWladimir J Alonso
Apr 20, 2013·The Journal of Infection·A MahamatC Viboud
Apr 10, 2014·PloS One·Jean-Paul ChretienF Ellis McKenzie
May 3, 2014·Journal of Virology·Anice C Lowen, John Steel
May 6, 2015·Current Epidemiology Reports·Sophia Ng, Aubree Gordon
Aug 1, 2015·PLoS Computational Biology·Wan YangJeffrey Shaman
Sep 10, 2016·Annals of the American Thoracic Society·Matthew J CummingsMax R O'Donnell
Nov 2, 2016·Proceedings of the National Academy of Sciences of the United States of America·Ethan R DeyleGeorge Sugihara
Mar 25, 2018·Influenza and Other Respiratory Viruses·Wan YangJeffrey Shaman
Feb 28, 2019·PLoS Computational Biology·Sarah C Kramer, Jeffrey Shaman
Nov 11, 2020·Proceedings of the National Academy of Sciences of the United States of America·Rachel E BakerBryan T Grenfell

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