Modeling interleukin-2-based immunotherapy in AIDS pathogenesis

Journal of Theoretical Biology
Marcel Joly, Darci Odloak

Abstract

In this paper, we sought to identify the CD4(+) T-cell dynamics in the course of HIV infection in response to continuous and intermittent intravenous courses of interleukin-2 (IL-2), the principal cytokine responsible for progression of CD4(+) T-lymphocytes from the G1 to the S phase of the cell cycle. Based on multivariate regression models, previous literature has concluded that the increase in survival of CD4(+) T-cell appears to be the critical mechanism leading to sustained CD4(+) T-cell levels in HIV-infected patients receiving intermittent IL-2 therapy. Underscored by comprehensive mathematical modeling, a major finding of the present work is related to the fact that, rather than due to any increase in survival of CD4(+) T-cells, the expressive, selective and sustained CD4(+) T-cell expansions following IL-2 administration may be related to the role of IL-2 in modulating the dynamics of Fas-dependent apoptotic pathways, such as activation-induced cell death (AICD) or HIV-specific apoptotic routes triggered by viral proteins.

References

Mar 7, 1992·Journal of Theoretical Biology·A R McLean, M A Nowak
Mar 1, 1993·Mathematical Biosciences·A S PerelsonR De Boer
Oct 31, 1996·The New England Journal of Medicine·J A KovacsH C Lane
May 30, 1998·Proceedings of the National Academy of Sciences of the United States of America·Z GrossmanW E Paul
Sep 30, 1998·Proceedings of the National Academy of Sciences of the United States of America·T B Kepler, A S Perelson
Jun 24, 2000·Clinical Immunology : the Official Journal of the Clinical Immunology Society·D L Farber
Jun 28, 2001·Clinical and Diagnostic Laboratory Immunology·P De Paoli
Apr 26, 2003·Mechanisms of Ageing and Development·Alexei A Romanyukha, Anatoli I Yashin
Oct 16, 2009·The New England Journal of Medicine·D AbramsD Wentworth
Aug 30, 2011·Journal of Theoretical Biology·K WendelsdorfH T Banks
Oct 2, 2012·Virology Journal·Julie GaribalJérôme Estaquier

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Citations

Aug 30, 2019·Current Opinion in Systems Biology·Jessica M Conway, Ruy M Ribeiro

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