Modeling Living Cells Response to Surface Tension and Chemical Patterns

ACS Applied Materials & Interfaces
Marco MacisFrancesco Zerbetto

Abstract

Mechanobiology is an important epigenetic factor. It influences cell functioning and bears on gene induction, protein synthesis, cell growth, and differentiation. In the presence of patterned chemical cues, living cells can take shapes that are far from that of a drop of fluid. These shapes are characterized by inward curvatures that are pinned at the points of location of the cues. The mechanochemical interactions that orchestrate cell behavior is simulated and controlled by modeling the cells as made by parcels of fluid. Cells become drops that are then endowed with the presence of additional forces, generated on the fly, that effectively make them active. With the proper choice of the forces, the phenomena that emerge from the dynamics match quantitatively the experiments. A combination of hydrophilic and lipophilic forces acting between the beads of fluid allows the active drop to respond to patterned cues and form squares, pentagons, hexagons, and flowers, just as living cells do.

References

Feb 1, 1988·Journal of Biomechanical Engineering·C DongS Chien
Jul 1, 1996·Biophysical Journal·R L Satcher, C F Dewey
Jul 21, 1996·Journal of Theoretical Biology·D StamenovićD E Ingber
May 30, 1997·Science·C S ChenD E Ingber
Aug 19, 1997·Proceedings of the National Academy of Sciences of the United States of America·C G Galbraith, M P Sheetz
Mar 30, 1999·Biophysical Journal·M Dembo, Y L Wang
Jan 13, 2000·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·D Shin, K Athanasiou
Jan 28, 2003·Biophysical Journal·Mark F Coughlin, Dimitrije Stamenović
Feb 16, 2005·Nature Materials·Julian C Shillcock, Reinhard Lipowsky
Dec 3, 2005·Journal of Biomechanics·C T LimS T Quek
Feb 24, 2006·Langmuir : the ACS Journal of Surfaces and Colloids·Bin Kong, Xiaozhen Yang
Jan 20, 2007·Science·Daisuke MizunoF C Mackintosh
Mar 24, 2007·Current Biology : CB·Damien CuvelierL Mahadevan
Jul 5, 2008·Biophysical Journal·Ilka B BischofsUlrich S Schwarz
Feb 7, 2009·Nature Reviews. Molecular Cell Biology·Benjamin GeigerAlexander D Bershadsky
Jul 18, 2009·PLoS Computational Biology·Taeyoon KimRoger D Kamm
Aug 8, 2009·Physical Review Letters·Ilka B BischofsUlrich S Schwarz
Mar 3, 2010·Proceedings of the National Academy of Sciences of the United States of America·Kristopher A KilianMilan Mrksich
May 21, 2010·Biophysical Journal·Dmitry A FedosovGeorge Em Karniadakis
Mar 1, 2011·Biophysical Journal·Shang-You TeePaul A Janmey
Mar 14, 2014·Soft Matter·Shiladitya BanerjeeM Cristina Marchetti
Aug 21, 2014·Biophysical Journal·Patrick W OakesMargaret L Gardel
Jan 31, 2015·ACS Applied Materials & Interfaces·Fabien Léonforte, Marcus Müller
Feb 5, 2015·ACS Applied Materials & Interfaces·Marco DallavalleFrancesco Zerbetto
Nov 6, 2015·ACS Applied Materials & Interfaces·Yan WangXin Dong Guo
Jan 19, 2016·Journal of Neuroscience Methods·Lyle Wiemerslage, Daewoo Lee
Feb 19, 2016·Soft Matter·Marco DallavalleFrancesco Zerbetto

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Citations

Dec 19, 2019·Journal of the Royal Society, Interface·H SureshV S Deshpande
May 8, 2020·Journal of Physics. Condensed Matter : an Institute of Physics Journal·Maurício Moreira-SoaresRui D M Travasso
Dec 2, 2020·Materials Science & Engineering. C, Materials for Biological Applications·Da-Wang ZhaoChao Liu

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