Modeling maternal fetal RSV F vaccine induced antibody transfer in guinea pigs

Vaccine
Gregory M GlennDavid C Flyer

Abstract

Protection of newborns and young infants against RSV disease via maternal immunization mediated by transplacental transfer of antibodies is under evaluation in third-trimester pregnant women with the RSV recombinant F nanoparticle vaccine (RSV F vaccine). Since the hemichorial placental architecture in guinea pigs and humans is similar, the guinea pig model was employed to assess RSV F vaccine immunogenicity in pregnant sows and to compare RSV-specific maternal antibody levels in their pups. Thirty (30) presumptive pregnant guinea pigs were immunized on gestational day 25 and 46 with placebo (PBS), 30μg RSV F, or 30μg RSV F+400μg aluminum phosphate. Sera at delivery/birth (sows/pups) and 15 and 30 days post-partum (pups) were analyzed for the presence of anti-F IgG, palivizumab-competitive antibody (PCA) and RSV/A microneutralization (MN). The rates of pregnancy and stillbirth were similar between controls and vaccinees. The vaccine induced high levels of anti-F IgG, PCA and MN in sows, with the highest levels observed in adjuvanted vaccinees. Placental transfer to pups was proportional to the maternal antibody levels, with concentration effects observed for all immune measures. The RSV F vaccine was safe and immunogenic in pre...Continue Reading

References

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Citations

Jun 18, 2016·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Joseph M CasterAndrew Wang
May 21, 2017·Expert Review of Vaccines·Tonya VillafanaMark T Esser
Aug 8, 2017·International Journal of Molecular Sciences·Silvia VandiniMarcello Lanari
May 18, 2018·Human Vaccines & Immunotherapeutics·Jorge C G BlancoStefanie N Vogel
Feb 10, 2018·NPJ Vaccines·Meghan S Vermillion, Sabra L Klein
May 5, 2017·Science Translational Medicine·Qing ZhuJoAnn A Suzich
Mar 1, 2019·Vaccines·Emily PhungTracy J Ruckwardt

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