Modeling membranes under a transmembrane potential

The Journal of Physical Chemistry. B
Lucie DelemotteMounir Tarek

Abstract

Accurate modeling of ion transport through synthetic and biological transmembrane channels has been so far a challenging problem. We introduce here a new method that allows one to study such transport under realistic biological conditions. We present results from molecular dynamics simulations of an ion channel formed by a peptide nanotube, embedded in a lipid bilayer, and subject to transmembrane potentials generated by asymmetric distributions of ions on both sides of the membrane. We show that the method is efficient for generating ionic currents and allows us to estimate the intrinsic conductance of the channel.

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Citations

May 25, 2010·Analytical and Bioanalytical Chemistry·Manyan WangStephen G Weber
May 31, 2012·The Journal of Membrane Biology·Lucie Delemotte, Mounir Tarek
Aug 14, 2012·The Journal of Membrane Biology·Peter KramarDamijan Miklavčič
Oct 6, 2012·Chemical Reviews·Christopher MaffeoAleksei Aksimentiev
Aug 14, 2012·Journal of the American Chemical Society·Marie BretonMounir Tarek
Jan 30, 2009·Journal of the American Chemical Society·Werner TreptowMichael L Klein
Apr 7, 2011·Physical Chemistry Chemical Physics : PCCP·Alessandro Venturini, Francesco Zerbetto
Dec 1, 2012·Nanoscale·Niraj ModiUlrich Kleinekathöfer
Mar 30, 2011·Proceedings of the National Academy of Sciences of the United States of America·Lucie DelemotteWerner Treptow
Oct 2, 2013·The Journal of General Physiology·Fatemeh Khalili-AraghiBenoît Roux
May 27, 2009·The Journal of Chemical Physics·Fernando E Herrera, Sergio Pantano
Jan 28, 2014·Bioelectrochemistry·Andraž PolakDamijan Miklavčič
Jan 10, 2016·Biochimica Et Biophysica Acta·Sonja A Kirsch, Rainer A Böckmann
Jun 2, 2009·Chemistry and Physics of Lipids·Alexander P Demchenko, Semen O Yesylevskyy
Jun 20, 2013·The Journal of Membrane Biology·Andraž PolakMounir Tarek
Feb 14, 2016·Biochimica Et Biophysica Acta·Carsten KutznerUlrich Zachariae
Nov 18, 2008·Biochimica Et Biophysica Acta·Siewert J MarrinkD Peter Tieleman
Oct 18, 2011·Biochimica Et Biophysica Acta·James GumbartBenoît Roux
Oct 7, 2009·Biophysical Journal·Soroosh PezeshkiUlrich Kleinekathöfer
Mar 26, 2016·Journal of Chemical Theory and Computation·Josef MelcrPavel Jungwirth
Feb 12, 2014·Biochimica Et Biophysica Acta·Marina A KasimovaLucie Delemotte
Dec 17, 2014·The Journal of Physical Chemistry. B·Andraž PolakDamijan Miklavčič
Jul 8, 2008·Biochimica Et Biophysica Acta·Durba SenguptaSiewert-Jan Marrink
Apr 23, 2009·Biophysical Journal·Robert Schulz, Ulrich Kleinekathöfer
Sep 14, 2013·Journal of Biomolecular Structure & Dynamics·Asmaa A A ElsheshinySarah A Harris
May 19, 2012·The Journal of Physical Chemistry. C, Nanomaterials and Interfaces·Jeffrey Comer, Aleksei Aksimentiev
Mar 5, 2013·The Journal of Physical Chemistry. B·Letícia StockMichael L Klein
Jul 6, 2014·The Journal of Physical Chemistry. B·Andrey A Gurtovenko, Anastasia S Lyulina
Jan 16, 2013·Biochemistry·Letícia StockWerner Treptow
Feb 7, 2009·Methods in Cell Biology·Kaihsu TaiMark S P Sansom
Nov 3, 2017·The Journal of Membrane Biology·F CastellaniP T Vernier
May 31, 2018·Physical Chemistry Chemical Physics : PCCP·Xubo LinAlemayehu A Gorfe
Nov 27, 2018·PLoS Computational Biology·Letícia StockWerner Treptow
Feb 21, 2019·Annual Review of Biophysics·Tadej KotnikDamijan Miklavčič
May 24, 2012·Organic & Biomolecular Chemistry·Cui-hong WangZijing Lin
Aug 29, 2019·The Journal of Physiological Sciences : JPS·Takashi Sumikama, Shigetoshi Oiki
Sep 13, 2019·The Journal of General Physiology·Harald BernsteinerAnna Stary-Weinzinger
Sep 17, 2020·The Journal of Chemical Physics·Xubo Lin, Alemayehu A Gorfe

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