Modeling metastasis in vivo

Carcinogenesis
Chand Khanna, Kent Hunter

Abstract

Metastasis, the spread of a tumor from its primary site to other parts of the body, continues to be the most significant problem in the field of cancer. Patients who present with metastatic disease or those who develop metastases after successful management of the primary tumor carry a universally grave prognosis. To improve treatment outcomes for these patients a broader understanding of the biology of metastases is necessary. The biological complexity that characterizes metastasis requires complex experimental systems for its study. To a large extent the modeling of this biological complexity is only possible using animal models. The following review will summarize the strengths and weaknesses of available in vivo models of metastasis including transplantable syngeneic mouse and human-mouse xenografts, genetically engineered mice and naturally occurring cancers of companion animals (pet dogs and cats). No single metastasis model is sufficient to answer all questions. As such, the selection of the optimal model(s) for each biological or translational question is necessary.

Citations

Sep 1, 2005·Clinical & Experimental Metastasis·Alexander D BorowskyJeffrey P Gregg
Dec 17, 2008·Clinical & Experimental Metastasis·Jennifer M KirsteinAnn F Chambers
Jul 9, 2013·Trends in Molecular Medicine·Marco DuranteKathryn D Held
Sep 6, 2005·Nature Genetics·Yeong-Gwan ParkKent W Hunter
Mar 6, 2010·Nature Protocols·Igor Mizgirev, Sergei Revskoy
Aug 12, 2009·Proceedings of the National Academy of Sciences of the United States of America·Sumitaka HasegawaTsuneo Saga
May 4, 2013·Carcinogenesis·Jodi A McKenzieDouglas Grossman
Aug 24, 2010·Journal of the National Cancer Institute·Amanda G LinkousDennis E Hallahan
Jan 18, 2006·Annual Review of Medicine·Chand Khanna, Lee J Helman
May 9, 2012·Sarcoma·Alexander B MohsenyAnne-Marie Cleton-Jansen
Apr 17, 2010·American Journal of Respiratory Cell and Molecular Biology·Zvi G FridlenderSteven M Albelda
Dec 15, 2007·The Journal of Clinical Investigation·Anne Grosse-WildeHenning Walczak
Feb 26, 2010·Nutrition & Metabolism·Thomas N Seyfried, Laura M Shelton
Jun 5, 2008·Molecular Cytogenetics·Jan T SollerJörn Bullerdiek
Aug 5, 2006·Breast Cancer Research : BCR·Anna Fantozzi, Gerhard Christofori
Jun 21, 2013·PLoS Genetics·María Isabel RodríguezF Javier Oliver
Nov 11, 2011·PloS One·Sergio Lavilla-AlonsoSari Pesonen
Dec 6, 2008·World Journal of Gastroenterology : WJG·Martijn W H LeendersInne H M Borel Rinkes
Apr 10, 2014·Disease Models & Mechanisms·Laure ThibaudeauDietmar W Hutmacher
Apr 21, 2012·Future Oncology·Geertje van der Horst, Gabri van der Pluijm
May 15, 2007·Proceedings of the National Academy of Sciences of the United States of America·Shashank JainJerry Ware
May 26, 2009·Clinical & Experimental Metastasis·Sylvia E Le DévédecBob van de Water
Apr 25, 2007·Leukemia & Lymphoma·Erwin M LeeRichard B Lock
Dec 17, 2015·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Dimosthenis AndreouPer-Ulf Tunn
Jun 7, 2005·Expert Review of Molecular Diagnostics·Yibin Kang
Oct 1, 2008·Expert Opinion on Drug Discovery·Matthias Kapischke, Alexandra Pries
Dec 17, 2015·Clinical & Experimental Metastasis·Rajesh K SharmaBodduluri Haribabu
Apr 15, 2016·Science Translational Medicine·Hui WangHongting Zheng
Feb 20, 2007·Mutation Research·Timothy J Moss, Lori L Wallrath
Sep 27, 2015·Journal of Controlled Release : Official Journal of the Controlled Release Society·Raquel De SouzaChristine Allen

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.