Modeling of adhesion, protrusion, and contraction coordination for cell migration simulations

Journal of Mathematical Biology
Y SakamotoM H Zaman

Abstract

Cell migration is a highly complex, dynamical biological phenomenon that involves precise spatio-temporal coordination of distinctive sub-processes including adhesion, protrusion, and contraction of the cell. Observations of individual tumor cell migration reveal that cells generally exhibit either mesenchymal-type or amoeboid-type migration modes in native like environments. However, it has also been observed that some migrating cells are capable of morphologically adapting to their environment by modifying their type of migration. Recent studies suggest in fact that changes in biophysical and biomechanical properties of tumor cells can reversibly control their transition from one type of migration to the other. These changes may be caused by internal cell biomechanical mechanisms as well as mechanical and topological properties of the extracellular matrix. In order to understand the complex transition between the two modes and the role played by internal cellular mechanics during migration, we have developed a novel axisymmetric hyperviscoelastic cell model to simulate the dynamical behavior of a migrating cell. Numerical results from our study quantitatively demonstrate that the biomechanical properties of the cell may play ...Continue Reading

References

Jan 27, 2000·Cell·D Hanahan, R A Weinberg
May 2, 2003·Nature Reviews. Cancer·Peter Friedl, Katarina Wolf
May 29, 2003·Biophysical Journal·David I ShreiberRobert T Tranquillo
Dec 6, 2003·Science·Anne J RidleyAlan Rick Horwitz
Dec 13, 2003·Bulletin of Mathematical Biology·Maria E Gracheva, Hans G Othmer
Apr 26, 2005·Biophysical Journal·Valérie M LaurentJean-Jacques Meister
May 24, 2005·Biophysical Journal·Muhammad H ZamanDouglas A Lauffenburger
May 26, 2006·Nature Reviews. Cancer·Patrick Mehlen, Alain Puisieux
Jul 13, 2006·Proceedings of the National Academy of Sciences of the United States of America·Muhammad H ZamanPaul Matsudaira
Sep 13, 2006·The Journal of Cell Biology·Marcus PrassManfred Radmacher
Apr 28, 2007·Annual Review of Biomedical Engineering·Paul A Janmey, Christopher A McCulloch
Jun 26, 2007·International Journal of Biological Sciences·Revathi Ananthakrishnan, Allen Ehrlicher
Apr 5, 2008·Journal of Cell Science·Yoshiaki Iwadate, Shigehiko Yumura
Nov 18, 2008·Nature Cell Biology·Lin JiGaudenz Danuser
Feb 18, 2009·The Journal of Cell Biology·Andrew D DoyleKenneth M Yamada
Mar 1, 2003·Journal of Statistical Physics·A Mogilner, D W Verzi
Jun 16, 2009·Current Opinion in Cell Biology·Tim Lämmermann, Michael Sixt
Oct 7, 2009·Biophysical Journal·Boris RubinsteinAlex Mogilner
Nov 17, 2009·Journal of Biomechanics·Jonathan StrickerMargaret L Gardel
Dec 3, 2009·The Journal of Cell Biology·Peter Friedl, Katarina Wolf
Dec 4, 2009·Molecular Biology of the Cell·Ruedi MeiliJuan C Lasheras
Sep 11, 2010·Current Opinion in Cell Biology·Victoria Sanz-Moreno, Christopher J Marshall
Jan 7, 2011·Integrative Biology : Quantitative Biosciences From Nano to Macro·Amit Pathak, Sanjay Kumar
Jul 30, 2011·Annals of Biomedical Engineering·Y SakamotoM H Zaman
Dec 14, 2011·Proceedings of the National Academy of Sciences of the United States of America·Noa OferKinneret Keren
Jun 26, 2012·Journal of Theoretical Biology·Rachele Allena, Denis Aubry

❮ Previous
Next ❯

Citations

Feb 7, 2017·PloS One·Wanho LeeYangjin Kim
Jul 19, 2013·Nature Reviews. Cancer·Muhammad H Zaman
Aug 28, 2020·PLoS Computational Biology·Ondrej MaxianWanda Strychalski
Nov 20, 2016·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·Meng Sun, Muhammad H Zaman
Aug 11, 2020·Biomechanics and Modeling in Mechanobiology·Eric J Campbell, Prosenjit Bagchi
Nov 17, 2020·APL Bioengineering·Gabriel ShatkinAdam J Engler
May 15, 2020·Biophysical Journal·Ismael FortunaRita M C de Almeida

❮ Previous
Next ❯

Related Concepts

Related Feeds

Biophysics of Adhesion

Alterations in cell adhesion can disrupt important cellular processes and lead to a variety of diseases, including cancer and arthritis. It is also essential for infectious organisms, such as bacteria or viruses, to cause diseases. Understanding the biophysics of cell adhesion can help understand these diseases. Discover the latest research on the biophysics of adhesion here.

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Cell Migration in Cancer and Metastasis

Migration of cancer cells into surrounding tissue and the vasculature is an initial step in tumor metastasis. Discover the latest research on cell migration in cancer and metastasis here.