Modeling of an Active Tablet Coating Process

Journal of Pharmaceutical Sciences
Gregor ToschkoffJohannes Khinast

Abstract

Tablet coating is a common unit operation in the pharmaceutical industry, during which a coating layer is applied to tablet cores. The coating uniformity of tablets in a batch is especially critical for active coating, that is, coating that contains an active pharmaceutical ingredient. In recent years, discrete element method (DEM) simulations became increasingly common for investigating tablet coating. In this work, DEM was applied to model an active coating process as closely as possible, using measured model parameters and non-spherical particles. We studied how operational conditions (rotation speed, fill level, number of nozzles, and spray rate) influence the coating uniformity. To this end, simulation runs were planned and interpreted according to a statistical design of (simulation) experiments. Our general goal was to achieve a deeper understanding of the process in terms of residence times and dimensionless scaling laws. With that regard, the results were interpreted in light of analytical models. The results were presented at various detail levels, ranging from an overview of all variations to in-depth considerations. It was determined that the biggest uniformity improvement in a realistic setting was achieved by incr...Continue Reading

References

Dec 16, 2005·AAPS PharmSciTech·Preetanshu Pandey, Richard Turton
Jan 20, 2007·AAPS PharmSciTech·Preetanshu PandeyRichard Turton
Jul 7, 2007·Pharmaceutical Development and Technology·Anand JoglekarJames Ergun
Jun 20, 2008·Journal of Pharmaceutical Sciences·William R KetterhagenBruno C Hancock
Feb 22, 2011·Breastfeeding Medicine : the Official Journal of the Academy of Breastfeeding Medicine·UNKNOWN U.S. Department of Health and Human Services
Mar 2, 2011·International Journal of Pharmaceutics·William R Ketterhagen
Jul 27, 2011·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·D M KollerJ G Khinast
Feb 4, 2012·International Journal of Pharmaceutics·Jennifer WangSailesh Varia
Sep 20, 2012·International Journal of Pharmaceutics·D BrockP Kleinebudde
Aug 31, 2013·International Journal of Pharmaceutics·Gregor Toschkoff, Johannes G Khinast
Sep 24, 2013·International Journal of Pharmaceutics·Sarah JustPeter Kleinebudde

❮ Previous
Next ❯

Citations

Dec 29, 2015·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·P BoehlingJ G Khinast
Apr 4, 2017·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·P BoehlingJ G Khinast
Jan 18, 2020·Drug Development and Industrial Pharmacy·Priscila Debastiani BarrosÉlcio José Bunhak
Mar 12, 2020·Sensors·Décio Alves-LimaHungyen Lin
Nov 28, 2020·AAPS PharmSciTech·Peter BoehlingJohannes G Khinast
Oct 20, 2018·Journal of Pharmaceutical Sciences·Peter BöhlingAvik Sarkar
Jun 16, 2021·AAPS PharmSciTech·William R KetterhagenJared A Baird

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

International Journal of Pharmaceutics
Gregor Toschkoff, Johannes Khinast
Journal of Pharmaceutical Sciences
Otto ScheibelhoferJohannes Khinast
Journal of Pharmaceutical Sciences
Anjali M Agrawal, Preetanshu Pandey
© 2021 Meta ULC. All rights reserved