Modeling of arterial and cardiopulmonary baroreflex control of heart rate

The American Journal of Physiology
T H DesaiR Mosqueda-Garcia

Abstract

We evaluated R-R interval changes (delta R-R interval) in 13 subjects (27 +/- 6 yr; 7 men and 6 women) as a function of blood pressure changes at the carotid sinus and aortic arch and central venous pressure changes at the cardiopulmonary receptors. Neck chamber pressure and suction were used to change pressure at the carotid sinus while lower body negative pressure, phenylephrine infusion, and nitroprusside infusion were used to change pressure at the carotid sinus (delta CSP), aortic arch (delta AAP), and cardiopulmonary receptors (delta CPP). Random effects regression analysis showed a significant linear relationship for delta R-R interval (-1.75 + 1.64 delta CSP + 15.40 delta AAP + 29.02 delta CPP + error), and the correlation (r) between the observed and predicted delta R-R interval was 0.82 (P < 0.00001). Sixty-seven percent of the delta R-R interval variability observed in the study is explained by the model. delta AAP accounts for approximately 63%, delta CSP for 14%, and delta CPP for 23% of the explained delta R-R interval.

Citations

Aug 22, 2001·American Journal of Physiology. Heart and Circulatory Physiology·B PumpP Norsk
Nov 16, 2001·American Journal of Physiology. Heart and Circulatory Physiology·R Mukkamala, R J Cohen
Nov 11, 2003·Journal of Applied Physiology·Ingo FietzeVirend K Somers
Oct 25, 2000·American Journal of Physiology. Heart and Circulatory Physiology·A PortaM Pagani
Jun 20, 2014·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Javier A Sala-MercadoRamakrishna Mukkamala

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