Modeling of dielectrophoretic transport of myoglobin molecules in microchannels.

Biomicrofluidics
Naga Siva Kumar Gunda, Sushanta Kumar Mitra

Abstract

Myoglobin is one of the premature identifying cardiac markers, whose concentration increases from 90 pgml or less to over 250 ngml in the blood serum of human beings after minor heart attack. Separation, detection, and quantification of myoglobin play a vital role in revealing the cardiac arrest in advance, which is the challenging part of ongoing research. In the present work, one of the electrokinetic approaches, i.e., dielectrophoresis (DEP), is chosen to separate the myoglobin. A mathematical model is developed for simulating dielectrophoretic behavior of a myoglobin molecule in a microchannel to provide a theoretical basis for the above application. This model is based on the introduction of a dielectrophoretic force and a dielectric myoglobin model. A dielectric myoglobin model is developed by approximating the shape of the myoglobin molecule as sphere, oblate, and prolate spheroids. A generalized theoretical expression for the dielectrophoretic force acting on respective shapes of the molecule is derived. The microchannel considered for analysis has an array of parallel rectangular electrodes at the bottom surface. The potential and electric field distributions are calculated using Green's theorem method and finite eleme...Continue Reading

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Citations

Aug 3, 2013·Biomicrofluidics·Asuka NakanoAlexandra Ros
Feb 13, 2013·Electrophoresis·Asuka Nakano, Alexandra Ros
Sep 1, 2011·Electrophoresis·Cornelius F Ivory, Soumya K Srivastava
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Feb 27, 2013·Sensors and Actuators. B, Chemical·Fernanda Camacho-AlanisAlexandra Ros
Feb 24, 2015·Bioanalysis·Fernanda Camacho-Alanis, Alexandra Ros
Dec 20, 2011·The Journal of Physical Chemistry. B·Kamatchi SankaranarayananReinhard Miller

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Methods Mentioned

BETA
electrophoresis
gel filtration
enzyme

Software Mentioned

PARDISO
COMSOL MULTIPHYSICS

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