Modeling of dispersed-drug release from two-dimensional matrix tablets

Biomaterials
Y ZhouX Y Wu

Abstract

A mathematical model was developed and analytical solutions were obtained for dispersed-drug release from two-dimensional matrix tablets in a perfect sink. This model can be used to describe kinetics of solute release from matrices with isotropic or anisotropic properties. Moving boundaries of dispersed-drug in both radial and axial directions and release kinetics were predicted by the model. Various factors influencing release kinetics were analyzed including the ratio of initial solute loading (C0) to solute solubility (Cs), the anisotropy of the matrix and the aspect ratio of tablet radius to the half-thickness. The model is also applicable to 1-D planar or 1-D cylindrical geometries when R/H is larger than 100 or smaller than 0.01.

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Citations

Jul 17, 2008·Biomechanics and Modeling in Mechanobiology·Fabio GalbuseraGabriele Dubini
May 24, 2011·Journal of Materials Science. Materials in Medicine·Xianping XiaChanghong Zhu
Apr 25, 2000·Journal of Controlled Release : Official Journal of the Controlled Release Society·J HuangX Y Wu
Jun 10, 2011·Journal of Pharmaceutical Sciences·Erik JämstorpGöran Frenning
Aug 28, 2007·Journal of Pharmaceutical Sciences·U BrohedeG Frenning
Oct 25, 2011·Journal of Controlled Release : Official Journal of the Controlled Release Society·Juergen Siepmann, Florence Siepmann
Nov 26, 2010·International Journal of Pharmaceutics·Göran Frenning
Sep 8, 2010·International Journal of Pharmaceutics·Ignacio M HelblingRicardo J A Grau
Sep 30, 2008·International Journal of Pharmaceutics·J Siepmann, F Siepmann
Aug 6, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·Göran FrenningMaria Strømme
Dec 20, 2011·International Journal of Pharmaceutics·Ignacio M HelblingJulio A Luna
Jan 10, 2020·International Journal of Pharmaceutics·J Siepmann, F Siepmann

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