PMID: 11932570Apr 5, 2002Paper

Modeling of end-tidal and arterial PCO2 gradient: comparison with experimental data

Medicine and Science in Sports and Exercise
Habib BenallalT Busso

Abstract

The aim of this study was to test whether a tidally ventilated homogeneous lung model can correctly describe arterial and end-tidal gas partial pressures and thus the difference in end-tidal and arterial gas partial pressures at rest and during exercise. The implemented mathematical modeling described variations during the breathing cycle in CO2 and O2 fractions, alveolar volume, and pulmonary capillary gas exchange. Experimental data were obtained from measurements performed by 17 healthy subjects at rest and during 40, 50, 65, and 75% exercise .VO(2max) on a cycle ergometer. VO2, VCO2, and PET,CO2 were continuously measured using the MedGraphics CPX/D gas exchange system. Arterial gases were measured in brachial artery blood samples drawn simultaneously with gas exchange. Cardiac output was measured using the CO2 rebreathing method corrected by the blood sample data. The model was driven using experimental data for ventilation, VO2, VCO2, and cardiac output. The mean difference and the upper and lower limits of agreement between measured and simulated data were -0.004, +0.84, and -0.84 Torr for Pa,CO2; -0.06, +0.64, and -0.76 Torr for Pa,O2; -1.96, +2.84, and -6.76 Torr for PET,CO2; and +7.20, +25.80, and -11.40 Torr for PET,...Continue Reading

References

Nov 1, 1979·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·N L JonesJ W Kane
Dec 7, 1992·Journal of Theoretical Biology·K B Saunders, A R Cummin
Apr 1, 1990·Journal of Applied Physiology·P A RobbinsD J Paterson
Jul 1, 1988·Journal of Applied Physiology·A R DouglasJ W Reed
Jul 1, 1965·Journal of Applied Physiology·K Klausen
Jun 1, 1983·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·A ZwartW R de Vries
May 1, 1981·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·D D Lobdell
Dec 1, 1995·Journal of Applied Physiology·C M St CroixD H Paterson
Jul 1, 1997·Journal of Applied Physiology·J S Williams, T G Babb
Jan 4, 2001·European Journal of Applied Physiology·H Benallal, T Busso
Jul 1, 1952·Journal of Applied Physiology·A B DUBOIS
Sep 1, 1958·Journal of Applied Physiology·J G DEFARES
Mar 1, 1965·Acta Physiologica Scandinavica·C M HESSER, G MATELL
Jan 1, 1952·Journal of Applied Physiology·A B DUBOISW O FENN

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Citations

Feb 6, 2013·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Hooman HamedaniRahim R Rizi
Sep 5, 2015·Biomedical Engineering Online·Axel RiedlingerKnut Möller
Jun 21, 2008·The Journal of Physiology·Shoji ItoJoseph A Fisher

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