Modeling of fungal biofilms using a rat central vein catheter.

Methods in Molecular Biology
Jeniel E NettDavid R Andes

Abstract

Candida frequently grows as a biofilm, or an adherent community of cells protected from both the host immune system and antimicrobial therapies. Biofilms represent the predominant mode of growth for many clinical infections, including those associated with placement of a medical device. Here, we describe a model for Candida biofilm infection of one important clinical niche, a venous catheter. This animal model system incorporates the anatomical site, immune components, and fluid dynamics of a patient venous catheter infection and can be used for study of biofilm formation, drug resistance, and gene expression.

Citations

Mar 15, 2015·Proceedings of the National Academy of Sciences of the United States of America·Kaitlin F MitchellDavid R Andes
Feb 24, 2016·Antimicrobial Agents and Chemotherapy·Jeniel E NettDavid R Andes
Jun 3, 2016·Microbiology and Molecular Biology Reviews : MMBR·David R Soll, Karla J Daniels
Aug 18, 2020·Infection and Drug Resistance·Thitinan KitisinPassanesh Sukphopetch
Sep 24, 2015·Microbiology Spectrum·Jeniel E Nett, David R Andes

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