Modeling of post-stroke stimulation of cortical tissue

Mathematical Biosciences
A BeuterV Volpert

Abstract

Following a stroke, cortical networks in the penumbra area become fragmented and partly deactivated. We develop a model to study the propagation of waves of electric potential in the cortical tissue with integro-differential equations arising in neural field models. The wave speed is characterized by the tissue excitability and connectivity determined through parameters of the model. Post-stroke tissue damage in the penumbra area creates a hypoconnectivity and decreases the speed of wave propagation. It is proposed that external stimulation could restore the wave speed in the penumbra area under certain conditions of the parameters. Model guided cortical stimulation could be used to improve the functioning of cortical networks.

Citations

Sep 3, 2020·Chaos·S BudzinskiyV Volpert

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain-Computer Interface

A brain-computer interface, also known as a brain-machine interface, is a bi-directional communication pathway between an external device and a wired brain. Here is the latest research on this topic.

Related Papers

Proceedings of the National Academy of Sciences of the United States of America
W J Trjitzinsky
The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Trisha A DwyerLiping Wang
Stroke; a Journal of Cerebral Circulation
Michel M ModoJohannes Boltze
Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics
S Coombes, C R Laing
© 2022 Meta ULC. All rights reserved