PMID: 20639856Jul 20, 2010Paper

Modeling of preclinical and early clinical stages of Parkinson's disease

Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova
V G KhaindravaM V Ugriumov

Abstract

The first symptoms of Parkinson's disease manifest 20-30 years after the disease onset when the most dopaminergic neurons degenerated. Therefore, it is necessary to work out preclinical diagnostics and preventive treatment of this disease. Modeling of preclinical and early stages of Parkinson's disease was conducted in mice using 1-methyl-4-phenyl-1,2,3,6-tetrahydropiridine (MPTP). The changes in motor behavior were not observed in mice by 14 day after MPTP injections in dose 12 mg/kg two times with interval of two hours. In the striatum, the region of dopaminergic axon projection, the content of dopamine and number of dopaminergic axons decreased by 57% and 59%, respectively, i.e. there were no changes in dopamine in single axons. In the substantia nigra, the region of dopamine neuron localization, the content of dopamine did not change though the total number of neurons decreased by 28%. However the dopamine content in remained neurons was higher by 77% compared to the control that indirectly indicated the compensatory enhancement of dopamine synthesis. After the MPTP injections in dose 4x12 mg/kg, there were changes in motor behavior of mice in the most sensitive tests. In the striatum, the dopamine content and number of dop...Continue Reading

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