Modeling of quantal neurotransmitter release kinetics in the presence of fixed and mobile calcium buffers.

Journal of Computational Neuroscience
Iskander R GilmanovEllya A Bukharaeva

Abstract

The local calcium concentration in the active zone of secretion determines the number and kinetics of neurotransmitter quanta released after the arrival of a nerve action potential in chemical synapses. The small size of mammalian neuromuscular junctions does not allow direct measurement of the correlation between calcium influx, the state of endogenous calcium buffers determining the local concentration of calcium and the time course of quanta exocytosis. In this work, we used computer modeling of quanta release kinetics with various levels of calcium influx and in the presence of endogenous calcium buffers with varying mobilities. The results of this modeling revealed the desynchronization of quanta release under low calcium influx in the presence of an endogenous fixed calcium buffer, with a diffusion coefficient much smaller than that of free Ca(2+), and synchronization occurred upon adding a mobile buffer. This corresponds to changes in secretion time course parameters found experimentally (Samigullin et al., Physiol Res 54:129-132, 2005; Bukharaeva et al., J Neurochem 100:939-949, 2007).

References

May 1, 1992·The Journal of Physiology·G J Augustine, E Neher
Jun 1, 1992·Current Opinion in Neurobiology·G J Augustine, E Neher
Feb 1, 1990·Biophysical Journal·F Sala, A Hernández-Cruz
Feb 1, 1986·Pflügers Archiv : European journal of physiology·I ParnasJ Dudel
Mar 1, 1968·The Journal of Physiology·B Katz, R Miledi
Dec 1, 1972·The Journal of Physiology·E F Barrett, C F Stevens
Nov 1, 1967·The Journal of Physiology·F A Dodge, R Rahamimoff
Jan 1, 1995·European Biophysics Journal : EBJ·R A GiniatullinF Vyskocil
Dec 20, 1994·Proceedings of the National Academy of Sciences of the United States of America·R H ChowE Neher
Sep 1, 1993·The Journal of Physiology·Z Zhou, E Neher
Nov 1, 1995·Neuropharmacology·E Neher
Apr 1, 1999·Annual Review of Physiology·B L Sabatini, W G Regehr
Apr 25, 2000·Biophysical Journal·M R BennettW G Gibson
Jun 12, 2001·Current Opinion in Neurobiology·G J Augustine
Nov 3, 2001·Pflügers Archiv : European journal of physiology·M I Glavinović, H R Rabie
Feb 5, 2002·The Journal of Physiology·Ella A BukharaevaFrantisek Vyskocil
Aug 17, 2002·Trends in Neurosciences·Jen-Wei Lin, Donald S Faber
Aug 31, 2002·Biophysical Journal·Victor MatveevRobert S Zucker
Feb 16, 1965·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·B KATZ, R MILEDI
Apr 28, 2004·Biophysical Journal·Victor MatveevArthur Sherman
May 14, 2004·Journal of Neurophysiology·Tariq N Allana, Jen-Wei Lin
Jan 7, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Thibault CollinIsabel Llano
Jan 22, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Andreas MüllerDirk Dietrich
Apr 12, 2005·Cell Calcium·Nail Burnashev, Andrei Rozov
May 28, 2005·Current Opinion in Neurobiology·Ralf Schneggenburger, Erwin Neher
Dec 22, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Vahid ShahrezaeiKerry R Delaney
Jan 11, 2007·Journal of Neurochemistry·Ellya A BukharaevaLev G Magazanik
Mar 3, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Martin MüllerRalf Schneggenburger

❮ Previous
Next ❯

Citations

Oct 3, 2009·Journal of Computational Neuroscience·Amparo Gil, Virginia González-Vélez
Nov 27, 2009·Journal of Neurophysiology·Xueyong WangMark M Rich
Jan 15, 2014·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Venera KhuzakhmetovaEllya Bukharaeva
Nov 3, 2010·The European Journal of Neuroscience·Irina V KovyazinaEllya A Bukharaeva
Jul 2, 2015·Journal of Computational Neuroscience·Anatoly SavelievEllya Bukharaeva
Jun 26, 2013·Biophysical Journal·Markus DittrichStephen D Meriney
Apr 5, 2019·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Venera KhuzakhmetovaGuzel Sitdikova

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.