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Modeling of the Enzyme-Substrate Complexes of Human Poly(ADP-Ribose) Polymerase 1

Biochemistry. Biokhimii︠a︡

Feb 23, 2020

D K NilovV K Švedas

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Abstract

Poly(ADP-ribose) polymerase 1 (PARP-1) is a key DNA repair enzyme and an important target in cancer treatment. Conventional methods of studying the reaction mechanism of PARP-1 have limitations because of the complex structure of PARP-1 substrates; however, the necessary data can be obt...read more

Mentioned in this Paper

Polymers
7-methylguanine
Multienzyme Complexes
Biochemical Reaction
Poly Adenosine Diphosphate Ribose
Molecular Modeling
Structure
PARP2 protein, human
Parp1 protein, mouse
Molecular Docking Simulation
Paper Details
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Modeling of the Enzyme-Substrate Complexes of Human Poly(ADP-Ribose) Polymerase 1

Biochemistry. Biokhimii︠a︡

Feb 23, 2020

D K NilovV K Švedas

PMID: 32079521

DOI: 10.1134/s0006297920010095

Abstract

Poly(ADP-ribose) polymerase 1 (PARP-1) is a key DNA repair enzyme and an important target in cancer treatment. Conventional methods of studying the reaction mechanism of PARP-1 have limitations because of the complex structure of PARP-1 substrates; however, the necessary data can be obt...read more

Mentioned in this Paper

Polymers
7-methylguanine
Multienzyme Complexes
Biochemical Reaction
Poly Adenosine Diphosphate Ribose
Molecular Modeling
Structure
PARP2 protein, human
Parp1 protein, mouse
Molecular Docking Simulation

Feeds With Similar Papers

Solar-To-Chemical Conversion

This feed focuses on the latest research pertaining to mechanisms that facilitate reduction-oxidation biocatalysis only using light energy as a source. Here is the latest research.

Poly(ADP-Ribose) Polymerases

Poly(ADP-Ribose) Polymerase (PARP) is an enzyme with several functions, including cell differentiation, proliferation, and DNA damage repair. Here is the latest research on PARP.

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Current Opinion in Structural Biology

PARP-1 mechanism for coupling DNA damage detection to poly(ADP-ribose) synthesis

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Paper Details
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