Modeling of Virtual Mechanical Circulatory Hemodynamics for Biventricular Heart Failure Support.

Cardiovascular Engineering and Technology
Dennis W HorvathJamshid H Karimov

Abstract

In this study, a mechanical circulatory support simulation tool was used to investigate the application of a unique device with two centrifugal pumps and one motor for the biventricular assist device (BVAD) support application. Several conditions-including a range of combined left and right systolic heart failure severities, aortic and pulmonary valve regurgitation, and combinations of high and low systemic and pulmonary vascular resistances-were considered in the simulation matrix. Relative advantages and limitations of using the device in BVAD applications are discussed. The simulated BVAD pump was based on the Cleveland Clinic pediatric continuous-flow total artificial heart (P-CFTAH), which is currently under development. Different combined disease states (n = 10) were evaluated to model the interaction with the BVAD, considering combinations of normal heart, moderate failure and severe systolic failure of the left and right ventricles, regurgitation of the aortic and pulmonary valves and combinations of vascular resistance. The virtual mock loop simulation tool (MATLAB; MathWorks®, Natick, MA) simulates the hemodynamics at the pump ports using a lumped-parameter model for systemic/pulmonary circulation characteristic input...Continue Reading

References

Sep 29, 2009·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Kiyotaka FukamachiLeonard A R Golding
Jul 16, 2015·The Journal of Thoracic and Cardiovascular Surgery·Jamshid H KarimovKiyotaka Fukamachi
Jan 25, 2018·Interactive Cardiovascular and Thoracic Surgery·Kiyotaka FukamachiNader Moazami
Mar 15, 2018·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·David J HorvathKiyotaka Fukamachi
Apr 29, 2018·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Jamshid H KarimovKiyotaka Fukamachi
Aug 4, 2018·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Takuma MiyamotoKiyotaka Fukamachi
Sep 4, 2018·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Palak ShahVictor D Pretorius
Aug 2, 2019·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Juliane ViereckePaul Mohacsi

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