Modeling planarian regeneration: a primer for reverse-engineering the worm.

PLoS Computational Biology
Daniel LoboMichael Levin

Abstract

A mechanistic understanding of robust self-assembly and repair capabilities of complex systems would have enormous implications for basic evolutionary developmental biology as well as for transformative applications in regenerative biomedicine and the engineering of highly fault-tolerant cybernetic systems. Molecular biologists are working to identify the pathways underlying the remarkable regenerative abilities of model species that perfectly regenerate limbs, brains, and other complex body parts. However, a profound disconnect remains between the deluge of high-resolution genetic and protein data on pathways required for regeneration, and the desired spatial, algorithmic models that show how self-monitoring and growth control arise from the synthesis of cellular activities. This barrier to progress in the understanding of morphogenetic controls may be breached by powerful techniques from the computational sciences-using non-traditional modeling approaches to reverse-engineer systems such as planaria: flatworms with a complex bodyplan and nervous system that are able to regenerate any body part after traumatic injury. Currently, the involvement of experts from outside of molecular genetics is hampered by the specialist literat...Continue Reading

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Citations

Jan 10, 2014·Journal of the Royal Society, Interface·Daniel LoboMichael Levin
Nov 10, 2012·Development Genes and Evolution·Jochen C Rink
Apr 12, 2016·Communicative & Integrative Biology·Douglas J BlackistonMichael Levin
Mar 8, 2016·Journal of Computational Biology : a Journal of Computational Molecular Cell Biology·Daniel LoboMichael Levin
Mar 12, 2016·Theoretical Biology & Medical Modelling·Natalie K Gordon, Richard Gordon
Aug 31, 2016·Communicative & Integrative Biology·Kelly G SullivanMichael Levin
Sep 11, 2014·Scientific Reports·Yu-Sheng LinPo-Hsiang Tsui
Jun 9, 2018·Photochemistry and Photobiology·Michael R HamblinVladimir Heiskanen
Jan 1, 2015·F1000Research·Beatrix P RubinAngelika Steger
Mar 5, 2020·Communicative & Integrative Biology·Chris Fields, Michael Levin
Jul 22, 2019·Environmental Science and Pollution Research International·Roya AminiTabriziKevin R Tucker
Oct 16, 2019·Journal of Theoretical Biology·Samantha Herath, Daniel Lobo
Sep 1, 2017·Bio Systems·Michael Levin, Christopher J Martyniuk
Jun 27, 2021·Journal of Mathematical Biology·Arnd ScheelChristoph Tenbrock

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Methods Mentioned

BETA
dissection
electrophoresis
amputations
amputation

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