PMID: 18406778Dec 1, 1996Paper

Modeling plasma membrane and endoplasmic reticulum excitability in pituitary cells

Trends in Endocrinology and Metabolism : TEM
J RinzelY X Li

Abstract

The response of gonadotrophs to secretagogues involves dose-dependent, complex dynamic patterns of electrical activity and inositol 1,4,5-trisphosphate (InsP(3))-induced Ca(2+) mobilization, including pulsatility and oscillations on multiple time scales from milliseconds to minutes. Detailed in vitro experiments have enabled the identification of key mechanisms that underlie the plasma membrane (PM) electrical excitability and endoplasmic reticulum (ER) calcium excitability. We summarize these findings and review computer simulations of a biophysical model that resynthesizes and couples these components and that reproduces quantitatively the observed time courses and dose-response characteristics, as well as effects of various pharamacological manipulations. The theory suggests that cytosolic calcium is the primary messenger in coordinating the PM and ER regenerative behaviors during ER depletion and refilling.

References

May 1, 1992·Endocrine Reviews·S S Stojilković, K J Catt
Oct 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·G W De Young, J Keizer
May 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·S S StojilkovićK J Catt
Sep 21, 1989·Nature·M J Berridge, R F Irvine
Nov 1, 1995·The American Journal of Physiology·Y X LiJ Rinzel
Aug 1, 1995·Molecular Biology of the Cell·J KeizerJ Rinzel
Jan 27, 1995·Cell·D E Clapham
Oct 11, 1994·Proceedings of the National Academy of Sciences of the United States of America·F W TseB Hille
Jan 4, 1994·Proceedings of the National Academy of Sciences of the United States of America·Y X LiS S Stojilković
Jan 28, 1993·Nature·M J Berridge
Mar 1, 1997·Biophysical Journal·Y X LiJ Rinzel
Dec 1, 1996·Trends in Endocrinology and Metabolism : TEM·S S Stojilkovic

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Citations

Dec 1, 1996·Trends in Endocrinology and Metabolism : TEM·S S Stojilkovic

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