Modeling precision genomic-based radiation dose response in rectal cancer.

Future Oncology
Zhigang YuanJessica M Frakes

Abstract

Aim: Genomic-based risk stratification to personalize radiation dose in rectal cancer. Patients & methods: We modeled genomic-based radiation dose response using the previously validated radiosensitivity index (RSI) and the clinically actionable genomic-adjusted radiation dose. Results: RSI of rectal cancer ranged from 0.19 to 0.81 in a bimodal distribution. A pathologic complete response rate of 21% was achieved in tumors with an RSI <0.31 at a minimal genomic-adjusted radiation dose of 29.76 when modeling RxRSI to the commonly prescribed physical dose of 50 Gy. RxRSI-based dose escalation to 55 Gy in tumors with an RSI of 0.31-0.34 could increase pathologic complete response by 10%. Conclusion: This study provides a theoretical platform for development of an RxRSI-based prospective trial in rectal cancer.

References

Jan 1, 1984·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·M OvergaardA Sell
Oct 6, 2000·International Journal of Radiation Oncology, Biology, Physics·A K ChanD R Johnson
Oct 22, 2004·The New England Journal of Medicine·Rolf SauerUNKNOWN German Rectal Cancer Study Group
Aug 17, 2005·Cancer Research·Javier F Torres-RocaTimothy Yeatman
Sep 9, 2009·International Journal of Radiation Oncology, Biology, Physics·Steven A EschrichJavier F Torres-Roca
Sep 9, 2009·International Journal of Radiation Oncology, Biology, Physics·Steven EschrichJavier F Torres-Roca
May 18, 2012·International Journal of Radiation Oncology, Biology, Physics·Anders JakobsenSoren R Rafaelsen
Jul 27, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Steven A EschrichJavier F Torres-Roca
Nov 15, 2013·Lancet·Hermann BrennerChristian Peter Pox
Oct 5, 2014·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Johannes Peter Maarten BurbachOnne Reerink
Aug 4, 2015·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Tobin StromRavi Shridhar
Oct 10, 2015·Oncotarget·Kamran A AhmedJimmy J Caudell
Oct 16, 2015·International Journal of Radiation Oncology, Biology, Physics·Javier F Torres-RocaSteven A Eschrich
Dec 17, 2015·Annals of Surgical Oncology·Eisar Al-SukhniSteven J Nurkin
Jun 21, 2016·International Journal of Radiation Oncology, Biology, Physics·Kamran A AhmedJavier F Torres-Roca
Aug 12, 2016·Journal of the National Cancer Institute·Milou H MartensGeerard L Beets
Dec 7, 2016·Nature Reviews. Clinical Oncology·Cornelis J A PuntLouis Vermeulen
Dec 21, 2016·The Lancet Oncology·Jacob G ScottJavier F Torres-Roca
Feb 8, 2018·Pathobiology : Journal of Immunopathology, Molecular and Cellular Biology·Xavier SagaertSanne Verbeek
May 8, 2018·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Kamran A AhmedJavier F Torres-Roca

❮ Previous
Next ❯

Methods Mentioned

BETA
imaging techniques

Clinical Trials Mentioned

NCT02603302
NCT01951521
NCT02505750

Software Mentioned

GARD
MATLAB

Related Concepts

Related Feeds

Cancer Genomics (Keystone)

Cancer genomics approaches employ high-throughput technologies to identify the complete catalog of somatic alterations that characterize the genome, transcriptome and epigenome of cohorts of tumor samples. Discover the latest research using such technologies in this feed.

Related Papers

The Lancet Oncology
Daniel E SprattTheodore S Lawrence
The Medical Journal of Australia
The Medical Journal of Australia
The Medical Journal of Australia
© 2021 Meta ULC. All rights reserved