Modeling Radiation Effects of Ultrasoft X Rays on the Basis of Amorphous Track Structure

Radiation Research
Tamara BuchThomas Friedrich

Abstract

There is experimental evidence that ultrasoft X rays (0.1-5 keV) show a higher biological effectiveness than high-energy photons. Similar to high-LET radiation, this is attributed to a rather localized dose distribution associated with a considerably smaller range of secondary electrons, which results in an increasing yield of double-strand breaks (DSBs) and potentially more complex lesions. We previously reported on the application of the Giant LOop Binary LEsion (GLOBLE) model to ultrasoft X rays, in which experimental values of the relative biological effectiveness (RBE) for DSB induction were used to show that this increasing DSB yield was sufficient to explain the enhanced effectiveness in the cell inactivation potential of ultrasoft X rays. Complementary to GLOBLE, we report here on a modeling approach to predict the increased DSB yield of ultrasoft X rays on the basis of amorphous track structure formed by secondary electrons, which was derived from Monte Carlo track structure simulations. This procedure is associated with increased production of single-strand break (SSB) clusters, which are caused by the highly localized energy deposition pattern induced by low-energy photons. From this, the RBE of ultrasoft X rays can ...Continue Reading

References

Jun 1, 1977·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·D T Goodhead, J Thacker
Aug 1, 1979·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·D T GoodheadR Cox
Apr 11, 1991·International Journal of Radiation Biology·C M Meger WellsM N Gould
Apr 1, 1986·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·J ThackerD T Goodhead
Jan 1, 1967·Advances in Biological and Medical Physics·H H Rossi
Nov 1, 1981·Physics in Medicine and Biology·D T GoodheadR Cox
Nov 1, 1994·International Journal of Radiation Biology·J F Ward
May 1, 1997·International Journal of Radiation Biology·H NikjooM Terrissol
Jun 29, 1999·Radiation and Environmental Biophysics·W FriedlandA Ottolenghi
Oct 18, 2001·Radiation Research·K M PriseB D Michael
Jan 5, 2002·Acta Oncologica·B Rydberg
May 25, 2002·Radiation Measurements·R Katz, F A Cucinotta
Aug 27, 2002·Radiation Protection Dosimetry·H NikjooD T Goodhead
Apr 8, 2003·Proceedings of the National Academy of Sciences of the United States of America·Kai Rothkamm, Markus Löbrich
Oct 29, 2004·Physics in Medicine and Biology·James F HainfeldHenry M Smilowitz
Feb 24, 2007·Radiation Research·Thilo Elsässer, Michael Scholz
Sep 11, 2007·The Journal of Chemical Physics·Bernd WinterIngolf V Hertel
Apr 30, 2010·Physics in Medicine and Biology·Hooshang Nikjoo, Lennart Lindborg
Aug 10, 2011·International Journal of Radiation Biology·Thomas FriedrichMichael Scholz
Nov 12, 2013·Physical Review Letters·Stephan ThürmerBernd Winter
Mar 4, 2014·Physics in Medicine and Biology·C WälzleinM Durante
Dec 5, 2014·Medical Physics·Piotr PaterMario A Bernal
Apr 18, 2015·Radiation Protection Dosimetry·T FriedrichM Scholz

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Citations

Jul 19, 2019·Nucleic Acids Research·Jakub A KochanPrzemek M Krawczyk
Apr 12, 2020·Radiation and Environmental Biophysics·Uwe SchneiderJürgen Besserer
Aug 3, 2019·International Journal of Molecular Sciences·Yi Zheng, Léon Sanche

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Methods Mentioned

BETA
X-ray

Software Mentioned

TRAX
Mathematica
LEM
GLOBLE

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