Modeling resistance to genetic control of insects

Journal of Theoretical Biology
Nina AlpheyLuke S Alphey

Abstract

The sterile insect technique is an area-wide pest control method that reduces pest populations by releasing mass-reared sterile insects which compete for mates with wild insects. Modern molecular tools have created possibilities for improving and extending the sterile insect technique. As with any new insect control method, questions arise about potential resistance. Genetic RIDL(®)(1) (Release of Insects carrying a Dominant Lethal) technology is a proposed modification of the technique, releasing insects that are homozygous for a repressible dominant lethal genetic construct rather than being sterilized by irradiation. Hypothetical resistance to the lethal mechanism is a potential threat to RIDL strategies' effectiveness. Using population genetic and population dynamic models, we assess the circumstances under which monogenic biochemically based resistance could have a significant impact on the effectiveness of releases for population control. We assume that released insects would be homozygous susceptible to the lethal genetic construct and therefore releases would have a built-in element of resistance dilution. We find that this effect could prevent or limit the spread of resistance to RIDL constructs; the outcomes are subje...Continue Reading

References

Aug 21, 2012·Mathematical Biosciences and Engineering : MBE·Djamila MoulayHee-Dae Kwon
Oct 29, 2013·Annual Review of Entomology·Luke Alphey
Apr 19, 2016·Evolutionary Applications·Philip T LeftwichTracey Chapman
Nov 7, 2016·Journal of Theoretical Biology·Benjamin Watkinson-Powell, Nina Alphey
Sep 18, 2012·Revista Do Instituto De Medicina Tropical De São Paulo·André Barretto Bruno Wilke, Mauro Toledo Marrelli
Feb 6, 2020·G3 : Genes - Genomes - Genetics·Katherine E KnudsenMaxwell J Scott
Jun 18, 2017·Biological Invasions·Tim Harvey-SamuelLuke Alphey
Jul 3, 2013·Pathogens and Global Health·Luke AlpheyCamilla Beech
Jun 26, 2018·Agricultural and Forest Entomology·Nina Alphey, Michael B Bonsall
Jun 20, 2020·Nature Communications·Yang ZhaoAlfred M Handler

Citations

Apr 15, 1997·Proceedings of the National Academy of Sciences of the United States of America·F GouldM Laster
Mar 8, 2005·Nature Biotechnology·Peng GongLuke S Alphey
Oct 18, 2005·Proceedings of the National Academy of Sciences of the United States of America·Bruce E TabashnikYves Carrière
Mar 28, 2006·Trends in Parasitology·Mauro Toledo MarrelliMarcelo Jacobs-Lorena
May 26, 2006·Proceedings of the National Academy of Sciences of the United States of America·C J HartleyJ G Oakeshott
Nov 28, 2006·Trends in Genetics : TIG·Richard H Ffrench-Constant
Jan 16, 2007·Toxicon : Official Journal of the International Society on Toxinology·Graham M Nicholson
Feb 27, 2007·Nature Biotechnology·Guoliang FuLuke S Alphey
Mar 22, 2007·BMC Biology·Hoang Kim PhucLuke S Alphey
May 24, 2007·Proceedings of the National Academy of Sciences of the United States of America·Michael P AtkinsonLawrence M Wein
Nov 2, 2007·Journal of Economic Entomology·Nina AlpheyLuke S Alphey
Sep 4, 2008·Proceedings. Biological Sciences·Fred GouldAlun L Lloyd
May 20, 2009·Journal of Economic Entomology·Nina AlpheyLuke S Alphey
Feb 24, 2010·Proceedings of the National Academy of Sciences of the United States of America·Guoliang FuLuke S Alphey

Related Concepts

Fertility
Embryo
Genes, Insect
In Silico
Biological Regulation
Transcription Repressor/Corepressor
No Data re: Ingredient
Pathogenic Organism
Toxin
Genetic Conditions, Dominant

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