Modeling risky decision-making in nonhuman animals: shared core features

Current Opinion in Behavioral Sciences
Sarah R Heilbronner

Abstract

Understanding the neural mechanisms of risky decision-making is critical to developing appropriate treatments for psychiatric disorders, problem gambling, and addiction to drugs of abuse. Probing neurobiological mechanisms requires the use of nonhuman animal models (particularly rhesus macaques, rats, and mice). However, there is considerable variation across species in risk preferences. Nevertheless, there are shared core features of risky decision-making present across species. As demonstrated with a wide variety of behavioral paradigms, modulators of risk preference observed in humans are readily replicated in model species. Thus, risky decision-making represents an important implementation of reward-guided decision-making that is feasibly modeled across species.

References

Nov 2, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Paul J CockerCatharine A Winstanley
Dec 15, 2015·Behavioral Neuroscience·Caitlin A OrsiniBarry Setlow

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Citations

Oct 23, 2018·The European Journal of Neuroscience·Bianca SieveritzGordon W Arbuthnott
Oct 23, 2019·Scientific Reports·Benjamin R EisenreichJan Zimmermann
Jan 18, 2019·Brain and Neuroscience Advances·Arjun RamakrishnanMichael L Platt
Aug 26, 2018·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Nicola M Grissom, Teresa M Reyes
Nov 21, 2020·Psychopharmacology·Jaime J CastrellonGregory R Samanez-Larkin
Jan 12, 2021·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Seng Bum Michael YooJohn M Pearson
Dec 16, 2019·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Lidia CabezaYvan Peterschmitt
Aug 12, 2021·Nature Communications·David J-N MaissonJan Zimmermann

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